Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | yjhX-yjhQ/YjhX-GNAT |
Location | 4534430..4535244 | Replicon | chromosome |
Accession | NZ_CP056036 | ||
Organism | Escherichia coli strain EC31 |
Toxin (Protein)
Gene name | yjhX | Uniprot ID | S1PA82 |
Locus tag | HUW39_RS21795 | Protein ID | WP_001054376.1 |
Coordinates | 4534430..4534687 (+) | Length | 86 a.a. |
Antitoxin (Protein)
Gene name | yjhQ | Uniprot ID | U9Z4B8 |
Locus tag | HUW39_RS21800 | Protein ID | WP_001309181.1 |
Coordinates | 4534699..4535244 (+) | Length | 182 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HUW39_RS21775 (4529690) | 4529690..4530670 | + | 981 | WP_000991438.1 | 9-O-acetyl-N-acetylneuraminic acid deacetylase | - |
HUW39_RS26445 (4530780) | 4530780..4530985 | + | 206 | Protein_4310 | HNH endonuclease | - |
HUW39_RS21780 (4531285) | 4531285..4532265 | - | 981 | WP_000019400.1 | IS5-like element IS5 family transposase | - |
HUW39_RS21785 (4532452) | 4532452..4533692 | - | 1241 | Protein_4312 | helicase YjhR | - |
HUW39_RS26450 (4533808) | 4533808..4533939 | + | 132 | WP_001309182.1 | hypothetical protein | - |
HUW39_RS21795 (4534430) | 4534430..4534687 | + | 258 | WP_001054376.1 | YjhX family toxin | Toxin |
HUW39_RS21800 (4534699) | 4534699..4535244 | + | 546 | WP_001309181.1 | N-acetyltransferase | Antitoxin |
HUW39_RS21805 (4535300) | 4535300..4536046 | + | 747 | WP_000354251.1 | class I SAM-dependent methyltransferase | - |
HUW39_RS21810 (4536215) | 4536215..4536433 | + | 219 | Protein_4317 | hypothetical protein | - |
HUW39_RS21815 (4536471) | 4536471..4536587 | + | 117 | Protein_4318 | VOC family protein | - |
HUW39_RS21820 (4536832) | 4536832..4537953 | + | 1122 | WP_000010829.1 | M42 family metallopeptidase | - |
HUW39_RS21825 (4537950) | 4537950..4538228 | + | 279 | WP_000722973.1 | PTS sugar transporter subunit IIB SgcB | - |
HUW39_RS21830 (4538240) | 4538240..4539553 | + | 1314 | WP_000460843.1 | PTS sugar transporter subunit IIC SgcC | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Genomic island | - | fimI / fimA / fimE / fimB | 4523017..4535244 | 12227 | ||
flank | IS/Tn | - | - | 4531285..4532265 | 980 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 9734.29 Da Isoelectric Point: 11.0090
>T162541 WP_001054376.1 NZ_CP056036:4534430-4534687 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR
Download Length: 258 bp
>T162541 NZ_CP071845:1423803-1424057 [Vibrio sp. SCSIO 43139]
ATGAGAATCGTATCTTTTACTGAAGCTAGAAATGGTCTTAAAGCTGTTTTGGACGGTGTAGTTAATGACGCTGATACAAC
AGTTATTACACGCCGTGATTCTGAAGATGCTGTGGTTATGTCTTTAGACTACTACAATAGCCTTATGGAGACCGTTCACT
TACTACGCTCTCCTCAAAACGCTGAACACCTAAACCGTTCGATAGCACAGTACCGCGCTGGTAAAACAACAACACGAGAG
TTAATTGATGAGTAG
ATGAGAATCGTATCTTTTACTGAAGCTAGAAATGGTCTTAAAGCTGTTTTGGACGGTGTAGTTAATGACGCTGATACAAC
AGTTATTACACGCCGTGATTCTGAAGATGCTGTGGTTATGTCTTTAGACTACTACAATAGCCTTATGGAGACCGTTCACT
TACTACGCTCTCCTCAAAACGCTGAACACCTAAACCGTTCGATAGCACAGTACCGCGCTGGTAAAACAACAACACGAGAG
TTAATTGATGAGTAG
Antitoxin
Download Length: 182 a.a. Molecular weight: 19956.90 Da Isoelectric Point: 6.3277
>AT162541 WP_001309181.1 NZ_CP056036:4534699-4535244 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT
Download Length: 546 bp
>AT162541 NZ_CP071845:1424050-1424319 [Vibrio sp. SCSIO 43139]
ATGAGTAGTAGTCAACGTTTACTATCGTGGACTGATGACGCTTGGGATGACTACCTGTATTGGCAAACTCAAGACAAGAA
AACACTCAAGCGCATCAACAAACTCATCAATGATGTAAAGCGCTCCCCATTTGAGGGTATCGGTAAACCAGAGCCGTTAA
AAGAGAACTTATCTGGTTTTTGGTCTCGTCGTGTTGATGACACTAATAGGCTTGTTTACGCAGTCGATGATCAAGCGATA
ACGATAATCTCGTGTCGTTACCACTACTAA
ATGAGTAGTAGTCAACGTTTACTATCGTGGACTGATGACGCTTGGGATGACTACCTGTATTGGCAAACTCAAGACAAGAA
AACACTCAAGCGCATCAACAAACTCATCAATGATGTAAAGCGCTCCCCATTTGAGGGTATCGGTAAACCAGAGCCGTTAA
AAGAGAACTTATCTGGTTTTTGGTCTCGTCGTGTTGATGACACTAATAGGCTTGTTTACGCAGTCGATGATCAAGCGATA
ACGATAATCTCGTGTCGTTACCACTACTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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