Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4533186..4534000 Replicon chromosome
Accession NZ_CP092702
Organism Escherichia coli strain S-P-C-029.01

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag MJ592_RS22015 Protein ID WP_001054376.1
Coordinates 4533743..4534000 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag MJ592_RS22010 Protein ID WP_001309181.1
Coordinates 4533186..4533731 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MJ592_RS21980 (4528877) 4528877..4530190 - 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -
MJ592_RS21985 (4530202) 4530202..4530480 - 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
MJ592_RS21990 (4530477) 4530477..4531598 - 1122 WP_000010829.1 M42 family metallopeptidase -
MJ592_RS21995 (4531843) 4531843..4531959 - 117 Protein_4302 VOC family protein -
MJ592_RS22000 (4531997) 4531997..4532215 - 219 Protein_4303 hypothetical protein -
MJ592_RS22005 (4532384) 4532384..4533130 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
MJ592_RS22010 (4533186) 4533186..4533731 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
MJ592_RS22015 (4533743) 4533743..4534000 - 258 WP_001054376.1 YjhX family toxin Toxin
MJ592_RS22020 (4534491) 4534491..4534622 - 132 WP_001309182.1 hypothetical protein -
MJ592_RS22025 (4534738) 4534738..4535978 + 1241 Protein_4308 helicase YjhR -
MJ592_RS22030 (4536246) 4536246..4536451 - 206 Protein_4309 HNH endonuclease -
MJ592_RS22035 (4536561) 4536561..4537541 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
MJ592_RS22040 (4537606) 4537606..4538712 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimB / fimE / fimA / fimI / fimC 4533186..4544976 11790


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T237002 WP_001054376.1 NZ_CP092702:c4534000-4533743 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T237002 NZ_LR778145:2322103-2322206 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT237002 WP_001309181.1 NZ_CP092702:c4533731-4533186 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT237002 NZ_LR778145:c2322244-2321973 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References