197281

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4418584..4419398 Replicon chromosome
Accession NZ_CP072054
Organism Escherichia coli strain K1508

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag J5N95_RS21250 Protein ID WP_001054376.1
Coordinates 4419141..4419398 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag J5N95_RS21245 Protein ID WP_001309181.1
Coordinates 4418584..4419129 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5N95_RS21215 (4414275) 4414275..4415588 - 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -
J5N95_RS21220 (4415600) 4415600..4415878 - 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
J5N95_RS21225 (4415875) 4415875..4416996 - 1122 WP_000010829.1 M42 family metallopeptidase -
J5N95_RS21230 (4417241) 4417241..4417357 - 117 Protein_4181 VOC family protein -
J5N95_RS21235 (4417395) 4417395..4417613 - 219 Protein_4182 hypothetical protein -
J5N95_RS21240 (4417782) 4417782..4418528 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
J5N95_RS21245 (4418584) 4418584..4419129 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
J5N95_RS21250 (4419141) 4419141..4419398 - 258 WP_001054376.1 YjhX family toxin Toxin
J5N95_RS21975 (4419889) 4419889..4420020 - 132 WP_001309182.1 hypothetical protein -
J5N95_RS21260 (4420136) 4420136..4421376 + 1241 Protein_4187 helicase YjhR -
J5N95_RS21980 (4421644) 4421644..4421849 - 206 Protein_4188 HNH endonuclease -
J5N95_RS21265 (4421959) 4421959..4422939 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
J5N95_RS21270 (4423004) 4423004..4424110 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimE / fimA / fimI / fimC 4418584..4430124 11540


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T197281 WP_001054376.1 NZ_CP072054:c4419398-4419141 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T197281 NZ_CP095864:3218618-3218917 [Gordonia sp. PP30]
ATGAAACGAGTGTTGTTCACCGCCTTGGCGCGTCGTGACATCGAAAGCATCTGGGACTTCACAGCGGCCACGTGGGATGC
CGACCAGGCCGACTACTACACCGACTCCATCGAAGAGTGCTGCATGCGCGTCGCCGCGGGAACGGTCGCCGGCAAGCCAA
CGACGAATCCGCCTGGCTACCGGAAGGCATTCGCCGGATCCCACCTGGTGTTCTATCGCGAGACCGAGGACATCGTGACG
ATTGTCCGCATTCTCCACCAACGACAAGACGTCGAACACCACCTCTCCGACTCCCCTTAG

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT197281 WP_001309181.1 NZ_CP072054:c4419129-4418584 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT197281 NZ_CP095864:3218373-3218621 [Gordonia sp. PP30]
ATGGCACGCAACACCTCGGTGATCCTCGGCGACCACTTCGCCGACTTCGTCGGAGCGCAGGTCGAATCCGGCCGATACGG
ATCCGCCAGCGACGTGATCCGGGCCGCCCTTCGCCTTCTCGAGGAACACGAAACACAAGTCCAGAACCTTCGAGACGCAC
TTCGAGCGGGCGAGGAATCGGGCGACGCCCAGCCGTTCGACTTCGAAGCGTTCAAGTCACGCAAGCGGGCCGAGCGCCGC
GATTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References