Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 2914438..2915252 Replicon chromosome
Accession NZ_CP102488
Organism Escherichia coli O15:H18 strain ST69

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag NUI00_RS14165 Protein ID WP_001054376.1
Coordinates 2914438..2914695 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag NUI00_RS14170 Protein ID WP_001309181.1
Coordinates 2914707..2915252 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUI00_RS14140 (2909726) 2909726..2910832 + 1107 WP_001309184.1 N-acetylneuraminate epimerase -
NUI00_RS14145 (2910897) 2910897..2911877 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
NUI00_RS14150 (2911987) 2911987..2912192 + 206 Protein_2770 HNH endonuclease -
NUI00_RS14155 (2912460) 2912460..2913700 - 1241 Protein_2771 helicase YjhR -
NUI00_RS14160 (2913816) 2913816..2913947 + 132 WP_001309182.1 hypothetical protein -
NUI00_RS14165 (2914438) 2914438..2914695 + 258 WP_001054376.1 YjhX family toxin Toxin
NUI00_RS14170 (2914707) 2914707..2915252 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
NUI00_RS14175 (2915308) 2915308..2916054 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
NUI00_RS14180 (2916223) 2916223..2916441 + 219 Protein_2776 hypothetical protein -
NUI00_RS14185 (2916479) 2916479..2916595 + 117 Protein_2777 VOC family protein -
NUI00_RS14190 (2916840) 2916840..2917961 + 1122 WP_000010829.1 M42 family metallopeptidase -
NUI00_RS14195 (2917958) 2917958..2918236 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
NUI00_RS14200 (2918248) 2918248..2919561 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimI / fimA / fimE / fimB 2904224..2915252 11028


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T253748 WP_001054376.1 NZ_CP102488:2914438-2914695 [Escherichia coli O15:H18]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT253748 WP_001309181.1 NZ_CP102488:2914707-2915252 [Escherichia coli O15:H18]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References