Detailed information of TA system TA054304

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 1110109..1110923
• Replicon: chromosome
• Accession: NZ_CP011495
• Organism: Escherichia coli strain NCM3722 isolate K-12

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: AA953_RS05430
• Protein ID: WP_001054376.1
• Coordinates: 1110666..1110923 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: U9Z4B8
• Locus tag: AA953_RS05425
• Protein ID: WP_001309181.1
• Coordinates: 1110109..1110654 (-)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AA953_RS05405	1105800..1107113	-	1314	WP_000460843.1	galactitol-specific PTS transporter subunit IIC	-
AA953_RS05410	1107125..1107403	-	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
AA953_RS05415	1107400..1108521	-	1122	WP_000010829.1	M42 family metallopeptidase	-
AA953_RS26820	1108766..1108882	-	117	Protein_1005	VOC family protein	-
AA953_RS25725	1108920..1109138	-	219	Protein_1006	hypothetical protein	-
AA953_RS05420	1109307..1110053	-	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
AA953_RS05425	1110109..1110654	-	546	WP_001309181.1	N-acetyltransferase	Antitoxin
AA953_RS05430	1110666..1110923	-	258	WP_001054376.1	hypothetical protein	Toxin
AA953_RS26275	1111300..1111545	-	246	Protein_1010	GNAT family N-acetyltransferase	-
AA953_RS05445	1111661..1112901	+	1241	Protein_1011	helicase YjhR	-
AA953_RS05450	1113484..1114464	-	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
AA953_RS05455	1114529..1115635	-	1107	WP_001309184.1	N-acetylneuraminate epimerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View HG738867 Escherichia coli str. K-12 substr. MC4100 Genomic island TA020089 4419085..4430625 0.004 View NC_000913 Escherichia coli str. K-12 substr. MG1655 Genomic island TA006279 4533239..4545029 0 View NC_007779 Escherichia coli str. K-12 substr. W3110 Genomic island TA021460 4537919..4549709 0 View NC_012759 Escherichia coli BW2952 Genomic island TA023876 4469997..4481537 0.004 View NC_017638 Escherichia coli DH1 Genomic island TA027426 4513009..4524807 0 View NZ_CP009273 Escherichia coli BW25113 Genomic island TA048705 4523056..4534846 0 View NZ_CP017979 Escherichia coli str. K-12 substr. W3110 strain K-12 substr. ZK126 Genomic island TA068445 4432698..4444488 0 View NZ_HG738867 Escherichia coli str. K-12 substr. MC4100 strain K-12 Genomic island TA285034 4419085..4430625 0.004	inside	Genomic island	-	fimB / fimE / fimA / fimI / fimC	1110109..1121898	11789

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T54304 WP_001054376.1 NZ_CP011495:c1110923-1110666 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T54304 NZ_CP011495:c1110923-1110666 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19956.90 Da
• Isoelectric Point: 6.3277

>AT54304 WP_001309181.1 NZ_CP011495:c1110654-1110109 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT54304 NZ_CP011495:c1110654-1110109 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: U9Z4B8