155026

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX(toxin)
Location 3571249..3572063 Replicon chromosome
Accession NZ_CP051719
Organism Escherichia coli strain SCU-116

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag HHJ31_RS17070 Protein ID WP_001054376.1
Coordinates 3571806..3572063 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID A0A8E0IVE5
Locus tag HHJ31_RS17065 Protein ID WP_001350781.1
Coordinates 3571249..3571794 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ31_RS17040 3566940..3568253 - 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -
HHJ31_RS17045 3568265..3568543 - 279 WP_000722973.1 PTS sugar transporter subunit IIB -
HHJ31_RS17050 3568540..3569661 - 1122 WP_000010829.1 M42 family metallopeptidase -
HHJ31_RS25025 3569906..3570022 - 117 Protein_3322 VOC family protein -
HHJ31_RS17055 3570060..3570278 - 219 Protein_3323 hypothetical protein -
HHJ31_RS17060 3570447..3571193 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
HHJ31_RS17065 3571249..3571794 - 546 WP_001350781.1 N-acetyltransferase Antitoxin
HHJ31_RS17070 3571806..3572063 - 258 WP_001054376.1 hypothetical protein Toxin
HHJ31_RS17075 3572440..3572685 - 246 Protein_3327 GNAT family N-acetyltransferase -
HHJ31_RS17080 3572801..3574041 + 1241 Protein_3328 helicase YjhR -
HHJ31_RS17085 3574624..3575604 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
HHJ31_RS17090 3575669..3576775 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimB / fimE / fimA / fimI / fimC 3571249..3583040 11791


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T155026 WP_001054376.1 NZ_CP051719:c3572063-3571806 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T155026 NZ_CP068602:1974767-1974869 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19974.91 Da        Isoelectric Point: 6.3277

>AT155026 WP_001350781.1 NZ_CP051719:c3571794-3571249 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFGKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAFIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT155026 NZ_CP068602:c1974876-1974731 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure

References