253523

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4543875..4544689 Replicon chromosome
Accession NZ_CP102378
Organism Escherichia coli strain JB41

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag NR351_RS22095 Protein ID WP_001054376.1
Coordinates 4544432..4544689 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag NR351_RS22090 Protein ID WP_001309181.1
Coordinates 4543875..4544420 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NR351_RS22060 (4539566) 4539566..4540879 - 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -
NR351_RS22065 (4540891) 4540891..4541169 - 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
NR351_RS22070 (4541166) 4541166..4542287 - 1122 WP_000010829.1 M42 family metallopeptidase -
NR351_RS22075 (4542532) 4542532..4542648 - 117 Protein_4295 VOC family protein -
NR351_RS22080 (4542686) 4542686..4542904 - 219 Protein_4296 hypothetical protein -
NR351_RS22085 (4543073) 4543073..4543819 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
NR351_RS22090 (4543875) 4543875..4544420 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
NR351_RS22095 (4544432) 4544432..4544689 - 258 WP_001054376.1 YjhX family toxin Toxin
NR351_RS22100 (4545180) 4545180..4545311 - 132 WP_001309182.1 hypothetical protein -
NR351_RS22105 (4545427) 4545427..4546667 + 1241 Protein_4301 helicase YjhR -
NR351_RS22110 (4546935) 4546935..4547140 - 206 Protein_4302 HNH endonuclease -
NR351_RS22115 (4547250) 4547250..4548230 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
NR351_RS22120 (4548295) 4548295..4549401 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimB / fimE / fimA / fimI / fimC 4543875..4555665 11790


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T253523 WP_001054376.1 NZ_CP102378:c4544689-4544432 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT253523 WP_001309181.1 NZ_CP102378:c4544420-4543875 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References