Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX(toxin)
Location 3590775..3591589 Replicon chromosome
Accession NZ_CP026491
Organism Escherichia coli strain HS13-1

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag C3K24_RS18585 Protein ID WP_001054376.1
Coordinates 3591332..3591589 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID A0A8E0IVE5
Locus tag C3K24_RS18580 Protein ID WP_001350781.1
Coordinates 3590775..3591320 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C3K24_RS18555 3586466..3587779 - 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -
C3K24_RS18560 3587791..3588069 - 279 WP_000722973.1 PTS sugar transporter subunit IIB -
C3K24_RS18565 3588066..3589187 - 1122 WP_000010832.1 M42 family metallopeptidase -
C3K24_RS29515 3589432..3589548 - 117 Protein_3407 VOC family protein -
C3K24_RS18570 3589586..3589804 - 219 Protein_3408 hypothetical protein -
C3K24_RS18575 3589973..3590719 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
C3K24_RS18580 3590775..3591320 - 546 WP_001350781.1 N-acetyltransferase Antitoxin
C3K24_RS18585 3591332..3591589 - 258 WP_001054376.1 hypothetical protein Toxin
C3K24_RS18595 3591966..3592211 - 246 Protein_3412 GNAT family N-acetyltransferase -
C3K24_RS18605 3592327..3593567 + 1241 Protein_3413 helicase YjhR -
C3K24_RS18610 3594150..3595130 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
C3K24_RS18615 3595195..3596301 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimB / fimE / fimA / fimI / fimC 3590775..3602566 11791


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T94988 WP_001054376.1 NZ_CP026491:c3591589-3591332 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T94988 NZ_CP026491:c3591589-3591332 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19974.91 Da        Isoelectric Point: 6.3277

>AT94988 WP_001350781.1 NZ_CP026491:c3591320-3590775 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFGKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAFIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT94988 NZ_CP026491:c3591320-3590775 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCGGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCTTTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure

References