205514

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 574038..574852 Replicon chromosome
Accession NZ_CP076344
Organism Escherichia coli strain AVS0096

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag KM937_RS02755 Protein ID WP_001054376.1
Coordinates 574595..574852 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID S1NWL7
Locus tag KM937_RS02750 Protein ID WP_001540600.1
Coordinates 574038..574583 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KM937_RS02720 (569729) 569729..571042 - 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -
KM937_RS02725 (571054) 571054..571332 - 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
KM937_RS02730 (571329) 571329..572450 - 1122 WP_000010829.1 M42 family metallopeptidase -
KM937_RS02735 (572695) 572695..572811 - 117 Protein_531 VOC family protein -
KM937_RS02740 (572849) 572849..573067 - 219 Protein_532 hypothetical protein -
KM937_RS02745 (573236) 573236..573982 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
KM937_RS02750 (574038) 574038..574583 - 546 WP_001540600.1 N-acetyltransferase Antitoxin
KM937_RS02755 (574595) 574595..574852 - 258 WP_001054376.1 YjhX family toxin Toxin
KM937_RS24720 (575343) 575343..575474 - 132 WP_001309182.1 hypothetical protein -
KM937_RS02765 (575590) 575590..576830 + 1241 Protein_537 helicase YjhR -
KM937_RS24725 (577098) 577098..577303 - 206 Protein_538 HNH endonuclease -
KM937_RS02770 (577413) 577413..578393 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
KM937_RS02775 (578458) 578458..579564 - 1107 WP_001774143.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimB / fimE / fimA / fimI / fimC 574038..585828 11790


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T205514 WP_001054376.1 NZ_CP076344:c574852-574595 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T205514 NZ_CP101705:c836343-835966 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCAGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19926.87 Da        Isoelectric Point: 6.3277

>AT205514 WP_001540600.1 NZ_CP076344:c574583-574038 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFGKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT205514 NZ_CP101705:c836764-836390 [Escherichia coli]
GTGTCAGACACTCTCCCCGGGACAACGCATCCCGACGATAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB S1NWL7

References