Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4409021..4409835 Replicon chromosome
Accession NZ_CP102379
Organism Escherichia coli strain BM28 lysU

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag NR350_RS21380 Protein ID WP_001054376.1
Coordinates 4409578..4409835 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag NR350_RS21375 Protein ID WP_001309181.1
Coordinates 4409021..4409566 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NR350_RS21345 (4404712) 4404712..4406025 - 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -
NR350_RS21350 (4406037) 4406037..4406315 - 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
NR350_RS21355 (4406312) 4406312..4407433 - 1122 WP_000010829.1 M42 family metallopeptidase -
NR350_RS21360 (4407678) 4407678..4407794 - 117 Protein_4153 VOC family protein -
NR350_RS21365 (4407832) 4407832..4408050 - 219 Protein_4154 hypothetical protein -
NR350_RS21370 (4408219) 4408219..4408965 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
NR350_RS21375 (4409021) 4409021..4409566 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
NR350_RS21380 (4409578) 4409578..4409835 - 258 WP_001054376.1 YjhX family toxin Toxin
NR350_RS21385 (4410326) 4410326..4410457 - 132 WP_001309182.1 hypothetical protein -
NR350_RS21390 (4410573) 4410573..4411813 + 1241 Protein_4159 helicase YjhR -
NR350_RS21395 (4412081) 4412081..4412286 - 206 Protein_4160 HNH endonuclease -
NR350_RS21400 (4412396) 4412396..4413376 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
NR350_RS21405 (4413441) 4413441..4414547 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimB / fimE / fimA / fimI / fimC 4409021..4422150 13129


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T253557 WP_001054376.1 NZ_CP102379:c4409835-4409578 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT253557 WP_001309181.1 NZ_CP102379:c4409566-4409021 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References