Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4505801..4506615 Replicon chromosome
Accession NZ_CP012125
Organism Escherichia coli strain DH1Ec095

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag ADS71_RS22165 Protein ID WP_001054376.1
Coordinates 4506358..4506615 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag ADS71_RS22160 Protein ID WP_001309181.1
Coordinates 4505801..4506346 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ADS71_RS22140 4501492..4502805 - 1314 WP_000460842.1 galactitol-specific PTS transporter subunit IIC -
ADS71_RS22145 4502817..4503095 - 279 WP_000722973.1 PTS sugar transporter subunit IIB -
ADS71_RS22150 4503092..4504213 - 1122 WP_000010829.1 M42 family metallopeptidase -
ADS71_RS25720 4504458..4504574 - 117 Protein_4206 VOC family protein -
ADS71_RS25120 4504612..4504830 - 219 Protein_4207 hypothetical protein -
ADS71_RS22155 4504999..4505745 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
ADS71_RS22160 4505801..4506346 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
ADS71_RS22165 4506358..4506615 - 258 WP_001054376.1 hypothetical protein Toxin
ADS71_RS25570 4506992..4507237 - 246 Protein_4211 GNAT family N-acetyltransferase -
ADS71_RS22180 4507353..4508593 + 1241 Protein_4212 helicase YjhR -
ADS71_RS22185 4509176..4510156 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
ADS71_RS22190 4510221..4511327 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimB / fimE / fimA / fimI / fimC 4505801..4517600 11799


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T55862 WP_001054376.1 NZ_CP012125:c4506615-4506358 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T55862 NZ_CP012125:c4506615-4506358 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT55862 WP_001309181.1 NZ_CP012125:c4506346-4505801 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT55862 NZ_CP012125:c4506346-4505801 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References