Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4533241..4534055 Replicon chromosome
Accession NZ_CP026350
Organism Escherichia coli strain 5FA

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag C2R13_RS23420 Protein ID WP_001054376.1
Coordinates 4533798..4534055 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag C2R13_RS23415 Protein ID WP_001309181.1
Coordinates 4533241..4533786 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2R13_RS23390 4528932..4530245 - 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -
C2R13_RS23395 4530257..4530535 - 279 WP_000722973.1 PTS sugar transporter subunit IIB -
C2R13_RS23400 4530532..4531653 - 1122 WP_000010829.1 M42 family metallopeptidase -
C2R13_RS24380 4531898..4532014 - 117 Protein_4264 VOC family protein -
C2R13_RS23405 4532052..4532270 - 219 Protein_4265 hypothetical protein -
C2R13_RS23410 4532439..4533185 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
C2R13_RS23415 4533241..4533786 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
C2R13_RS23420 4533798..4534055 - 258 WP_001054376.1 hypothetical protein Toxin
C2R13_RS23430 4534432..4534677 - 246 Protein_4269 GNAT family N-acetyltransferase -
C2R13_RS23440 4534793..4536033 + 1241 Protein_4270 helicase YjhR -
C2R13_RS23445 4536616..4537596 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
C2R13_RS23450 4537661..4538767 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimB / fimE / fimA / fimI / fimC 4533241..4545031 11790


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T94227 WP_001054376.1 NZ_CP026350:c4534055-4533798 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T94227 NZ_CP026350:c4534055-4533798 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT94227 WP_001309181.1 NZ_CP026350:c4533786-4533241 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT94227 NZ_CP026350:c4533786-4533241 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References