Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 1919796..1920610 Replicon chromosome
Accession NZ_CP043295
Organism Escherichia coli strain WCHEC040047

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag FYK54_RS09250 Protein ID WP_001054376.1
Coordinates 1919796..1920053 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag FYK54_RS09255 Protein ID WP_001309181.1
Coordinates 1920065..1920610 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYK54_RS09225 (1915084) 1915084..1916190 + 1107 WP_001309184.1 N-acetylneuraminate epimerase -
FYK54_RS09230 (1916255) 1916255..1917235 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
FYK54_RS09235 (1917345) 1917345..1917550 + 206 Protein_1810 HNH endonuclease -
FYK54_RS09240 (1917818) 1917818..1919058 - 1241 Protein_1811 helicase YjhR -
FYK54_RS09245 (1919174) 1919174..1919305 + 132 WP_001309182.1 hypothetical protein -
FYK54_RS09250 (1919796) 1919796..1920053 + 258 WP_001054376.1 YjhX family toxin Toxin
FYK54_RS09255 (1920065) 1920065..1920610 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
FYK54_RS09260 (1920666) 1920666..1921412 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
FYK54_RS09265 (1921581) 1921581..1921799 + 219 Protein_1816 hypothetical protein -
FYK54_RS09270 (1921837) 1921837..1921953 + 117 Protein_1817 VOC family protein -
FYK54_RS09275 (1922198) 1922198..1923319 + 1122 WP_000010829.1 M42 family metallopeptidase -
FYK54_RS09280 (1923316) 1923316..1923594 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
FYK54_RS09285 (1923606) 1923606..1924919 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimI / fimA / fimE / fimB 1909583..1920610 11027


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T138271 WP_001054376.1 NZ_CP043295:1919796-1920053 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T138271 NZ_CP057505:1911852-1911955 [Escherichia fergusonii]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT138271 WP_001309181.1 NZ_CP043295:1920065-1920610 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT138271 NZ_CP057505:c1911993-1911759 [Escherichia fergusonii]
AAAGTCAGCGAAGGGAATTTTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATGTTAAAAACC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References