Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4534837..4535651 Replicon chromosome
Accession NZ_CP019629
Organism Escherichia coli strain MGY

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag BWL12_RS23565 Protein ID WP_001054376.1
Coordinates 4535394..4535651 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag BWL12_RS23560 Protein ID WP_001309181.1
Coordinates 4534837..4535382 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BWL12_RS23530 4530528..4531841 - 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -
BWL12_RS23535 4531853..4532131 - 279 WP_000722973.1 PTS sugar transporter subunit IIB -
BWL12_RS23540 4532128..4533249 - 1122 WP_000010829.1 M42 family metallopeptidase -
BWL12_RS24920 4533494..4533610 - 117 Protein_4271 VOC family protein -
BWL12_RS23550 4533648..4533866 - 219 Protein_4272 hypothetical protein -
BWL12_RS23555 4534035..4534781 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
BWL12_RS23560 4534837..4535382 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
BWL12_RS23565 4535394..4535651 - 258 WP_001054376.1 hypothetical protein Toxin
BWL12_RS24625 4536028..4536273 - 246 Protein_4276 GNAT family N-acetyltransferase -
BWL12_RS23580 4536389..4537629 + 1241 Protein_4277 helicase YjhR -
BWL12_RS23590 4538212..4539192 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
BWL12_RS23595 4539257..4540363 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimB / fimE / fimA / fimI / fimC 4534837..4546627 11790


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T73098 WP_001054376.1 NZ_CP019629:c4535651-4535394 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T73098 NZ_CP019629:c4535651-4535394 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT73098 WP_001309181.1 NZ_CP019629:c4535382-4534837 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT73098 NZ_CP019629:c4535382-4534837 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References