210516

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 783600..784414 Replicon chromosome
Accession NZ_CP079993
Organism Escherichia coli strain EV36

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag KYK84_RS03790 Protein ID WP_001054376.1
Coordinates 784157..784414 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag KYK84_RS03785 Protein ID WP_001309181.1
Coordinates 783600..784145 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYK84_RS03755 (779291) 779291..780604 - 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -
KYK84_RS03760 (780616) 780616..780894 - 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
KYK84_RS03765 (780891) 780891..782012 - 1122 WP_000010829.1 M42 family metallopeptidase -
KYK84_RS03770 (782257) 782257..782373 - 117 Protein_743 VOC family protein -
KYK84_RS03775 (782411) 782411..782629 - 219 Protein_744 hypothetical protein -
KYK84_RS03780 (782798) 782798..783544 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
KYK84_RS03785 (783600) 783600..784145 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
KYK84_RS03790 (784157) 784157..784414 - 258 WP_001054376.1 YjhX family toxin Toxin
KYK84_RS03795 (784905) 784905..785036 - 132 WP_001309182.1 hypothetical protein -
KYK84_RS03800 (785152) 785152..786392 + 1241 Protein_749 helicase YjhR -
KYK84_RS03805 (786660) 786660..786865 - 206 Protein_750 HNH endonuclease -
KYK84_RS03810 (786975) 786975..787955 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
KYK84_RS03815 (788020) 788020..789126 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimB / fimE / fimA / fimI / fimC 783600..795390 11790


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T210516 WP_001054376.1 NZ_CP079993:c784414-784157 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T210516 NZ_CP104533:c4564918-4564745 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTTCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT210516 WP_001309181.1 NZ_CP079993:c784145-783600 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT210516 NZ_CP104533:c4565242-4564946 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References