232637

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4522226..4523040 Replicon chromosome
Accession NZ_CP091065
Organism Escherichia coli strain DOC14

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag L1123_RS21970 Protein ID WP_001054376.1
Coordinates 4522783..4523040 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag L1123_RS21965 Protein ID WP_001309181.1
Coordinates 4522226..4522771 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1123_RS21935 (4517917) 4517917..4519230 - 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -
L1123_RS21940 (4519242) 4519242..4519520 - 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
L1123_RS21945 (4519517) 4519517..4520638 - 1122 WP_000010829.1 M42 family metallopeptidase -
L1123_RS21950 (4520883) 4520883..4520999 - 117 Protein_4274 VOC family protein -
L1123_RS21955 (4521037) 4521037..4521255 - 219 Protein_4275 hypothetical protein -
L1123_RS21960 (4521424) 4521424..4522170 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
L1123_RS21965 (4522226) 4522226..4522771 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
L1123_RS21970 (4522783) 4522783..4523040 - 258 WP_001054376.1 YjhX family toxin Toxin
L1123_RS21975 (4523531) 4523531..4523662 - 132 WP_001309182.1 hypothetical protein -
L1123_RS21980 (4523778) 4523778..4525018 + 1241 Protein_4280 helicase YjhR -
L1123_RS21985 (4525286) 4525286..4525491 - 206 Protein_4281 HNH endonuclease -
L1123_RS21990 (4525601) 4525601..4526581 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
L1123_RS21995 (4526646) 4526646..4527752 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimB / fimE / fimA / fimI / fimC 4522226..4534016 11790


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T232637 WP_001054376.1 NZ_CP091065:c4523040-4522783 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T232637 NZ_CP127848:2025821-2025924 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT232637 WP_001309181.1 NZ_CP091065:c4522771-4522226 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT232637 NZ_CP127848:c2025962-2025691 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References