92825

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4516555..4517369 Replicon chromosome
Accession NZ_CP026027
Organism Escherichia coli strain LIM

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag C2H82_RS23345 Protein ID WP_001054376.1
Coordinates 4517112..4517369 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag C2H82_RS23340 Protein ID WP_001309181.1
Coordinates 4516555..4517100 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2H82_RS23315 4512246..4513559 - 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -
C2H82_RS23320 4513571..4513849 - 279 WP_000722973.1 PTS sugar transporter subunit IIB -
C2H82_RS23325 4513846..4514967 - 1122 WP_000010829.1 M42 family metallopeptidase -
C2H82_RS24245 4515212..4515328 - 117 Protein_4249 VOC family protein -
C2H82_RS23330 4515366..4515584 - 219 Protein_4250 hypothetical protein -
C2H82_RS23335 4515753..4516499 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
C2H82_RS23340 4516555..4517100 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
C2H82_RS23345 4517112..4517369 - 258 WP_001054376.1 hypothetical protein Toxin
C2H82_RS23355 4517746..4517991 - 246 Protein_4254 GNAT family N-acetyltransferase -
C2H82_RS23365 4518107..4519347 + 1241 Protein_4255 helicase YjhR -
C2H82_RS23370 4519930..4520910 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
C2H82_RS23375 4520975..4522081 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimB / fimE / fimA / fimI / fimC 4516555..4528345 11790


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T92825 WP_001054376.1 NZ_CP026027:c4517369-4517112 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T92825 NZ_CP026027:c4517369-4517112 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT92825 WP_001309181.1 NZ_CP026027:c4517100-4516555 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT92825 NZ_CP026027:c4517100-4516555 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References