256341

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4358374..4359188 Replicon chromosome
Accession NZ_CP103718
Organism Escherichia coli strain 1579

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag M5S87_RS20970 Protein ID WP_001054376.1
Coordinates 4358374..4358631 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag M5S87_RS20975 Protein ID WP_001309181.1
Coordinates 4358643..4359188 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S87_RS20945 (4353662) 4353662..4354768 + 1107 WP_001309184.1 N-acetylneuraminate epimerase -
M5S87_RS20950 (4354833) 4354833..4355813 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
M5S87_RS20955 (4355923) 4355923..4356128 + 206 Protein_4100 HNH endonuclease -
M5S87_RS20960 (4356396) 4356396..4357636 - 1241 Protein_4101 helicase YjhR -
M5S87_RS20965 (4357752) 4357752..4357883 + 132 WP_001309182.1 hypothetical protein -
M5S87_RS20970 (4358374) 4358374..4358631 + 258 WP_001054376.1 YjhX family toxin Toxin
M5S87_RS20975 (4358643) 4358643..4359188 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
M5S87_RS20980 (4359244) 4359244..4359990 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
M5S87_RS20985 (4360159) 4360159..4360377 + 219 Protein_4106 hypothetical protein -
M5S87_RS20990 (4360415) 4360415..4360531 + 117 Protein_4107 VOC family protein -
M5S87_RS20995 (4360776) 4360776..4361897 + 1122 WP_000010829.1 M42 family metallopeptidase -
M5S87_RS21000 (4361894) 4361894..4362172 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
M5S87_RS21005 (4362184) 4362184..4363497 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimI / fimA / fimE / fimB 4348161..4359188 11027
inside Genomic island - fimB 4350868..4359188 8320


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T256341 WP_001054376.1 NZ_CP103718:4358374-4358631 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT256341 WP_001309181.1 NZ_CP103718:4358643-4359188 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References