Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 575407..576221 Replicon chromosome
Accession NZ_CP116115
Organism Escherichia coli strain DETEC-P793

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag PIC92_RS02785 Protein ID WP_001054376.1
Coordinates 575964..576221 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID S1NWL7
Locus tag PIC92_RS02780 Protein ID WP_001540600.1
Coordinates 575407..575952 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC92_RS02750 (571098) 571098..572411 - 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -
PIC92_RS02755 (572423) 572423..572701 - 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
PIC92_RS02760 (572698) 572698..573819 - 1122 WP_000010829.1 M42 family metallopeptidase -
PIC92_RS02765 (574064) 574064..574180 - 117 Protein_535 VOC family protein -
PIC92_RS02770 (574218) 574218..574436 - 219 Protein_536 hypothetical protein -
PIC92_RS02775 (574605) 574605..575351 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
PIC92_RS02780 (575407) 575407..575952 - 546 WP_001540600.1 N-acetyltransferase Antitoxin
PIC92_RS02785 (575964) 575964..576221 - 258 WP_001054376.1 YjhX family toxin Toxin
PIC92_RS02790 (576712) 576712..576843 - 132 WP_001309182.1 hypothetical protein -
PIC92_RS02795 (576959) 576959..578199 + 1241 Protein_541 helicase YjhR -
PIC92_RS02800 (578467) 578467..578672 - 206 Protein_542 HNH endonuclease -
PIC92_RS02805 (578782) 578782..579762 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
PIC92_RS02810 (579827) 579827..580933 - 1107 WP_001774143.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimB / fimE / fimA / fimI / fimC 575407..587197 11790


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T268054 WP_001054376.1 NZ_CP116115:c576221-575964 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19926.87 Da        Isoelectric Point: 6.3277

>AT268054 WP_001540600.1 NZ_CP116115:c575952-575407 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFGKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB S1NWL7

References