171732

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 3513272..3514086 Replicon chromosome
Accession NZ_CP060953
Organism Escherichia coli strain EC8

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag H9195_RS16995 Protein ID WP_001054376.1
Coordinates 3513829..3514086 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID S1NWL7
Locus tag H9195_RS16990 Protein ID WP_001540600.1
Coordinates 3513272..3513817 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9195_RS16960 (3508963) 3508963..3510276 - 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -
H9195_RS16965 (3510288) 3510288..3510566 - 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
H9195_RS16970 (3510563) 3510563..3511684 - 1122 WP_000010829.1 M42 family metallopeptidase -
H9195_RS16975 (3511929) 3511929..3512045 - 117 Protein_3319 VOC family protein -
H9195_RS16980 (3512083) 3512083..3512301 - 219 Protein_3320 hypothetical protein -
H9195_RS16985 (3512470) 3512470..3513216 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
H9195_RS16990 (3513272) 3513272..3513817 - 546 WP_001540600.1 N-acetyltransferase Antitoxin
H9195_RS16995 (3513829) 3513829..3514086 - 258 WP_001054376.1 YjhX family toxin Toxin
H9195_RS17000 (3514577) 3514577..3514708 - 132 WP_001309182.1 hypothetical protein -
H9195_RS17005 (3514824) 3514824..3516064 + 1241 Protein_3325 helicase YjhR -
H9195_RS17010 (3516332) 3516332..3516537 - 206 Protein_3326 HNH endonuclease -
H9195_RS17015 (3516647) 3516647..3517627 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
H9195_RS17020 (3517692) 3517692..3518798 - 1107 WP_001774143.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimB / fimE / fimA / fimI / fimC 3513272..3525062 11790


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T171732 WP_001054376.1 NZ_CP060953:c3514086-3513829 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T171732 NZ_CP078069:847471-847764 [Comamonas sp. NLF-1-9]
ATGGCCAAAGCCAAAGAAACCTTCACCCGCTACGACACCGCCGACTATCTCGAGACCGAAGAAGACATTGCGGCCTATCT
CACCGCTTGCGCTGAAGAAGATGATCCGGCGCTCTTTCTTGCCGCCCTGGGCGATGTGGCGCGTGCCCGCAATATCACCC
AGCTCGCTGCCCAAACTGGCCTGACCCGCATGGGCCTCTACAAGGCTTTGTCTGGCACGGGCAATCCGAGCTTCGCTACC
GTCAGCAAGGTGGCGCACGCCCTGGGGCTGAGAATCACGGTAGCTGCTGCCTAG

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19926.87 Da        Isoelectric Point: 6.3277

>AT171732 WP_001540600.1 NZ_CP060953:c3513817-3513272 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFGKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT171732 NZ_CP078069:847172-847468 [Comamonas sp. NLF-1-9]
GTGTACGAAGTCCTCAAAAGCAGCACGTTCGACAGCTGGCTCCGTGGCCTGCGTGACCGAGACGCGAAAGCCAGGATCGA
GGTTCGCATCAGGCGTCTTTCTCTTGGGAATCCCGGCCAGTTTCGGGCGCTCAAAGAAGGCGTCAATGAGCTCAAGATCG
ATCACGGCCCCGGCTACCGCGTCTATTACACGTTCAAGGGCAAGACGCTGATCCTGTTGCTTTGCGGCGGGGACAAGTCC
TCGCAAGGCAAGGACATACGACTCGCCATGGATATCGCCGCTTCCTGGGAGAACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB S1NWL7

References