192623

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 1114325..1115139 Replicon chromosome
Accession NZ_CP070007
Organism Escherichia coli strain FDAARGOS_1288

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag I6K18_RS05445 Protein ID WP_001054376.1
Coordinates 1114325..1114582 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag I6K18_RS05450 Protein ID WP_001309181.1
Coordinates 1114594..1115139 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K18_RS05425 (1109585) 1109585..1110565 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
I6K18_RS28240 (1110675) 1110675..1110880 + 206 Protein_1061 HNH endonuclease -
I6K18_RS05430 (1111180) 1111180..1112160 - 981 WP_000019400.1 IS5-like element IS5 family transposase -
I6K18_RS05435 (1112347) 1112347..1113587 - 1241 Protein_1063 helicase YjhR -
I6K18_RS28245 (1113703) 1113703..1113834 + 132 WP_001309182.1 hypothetical protein -
I6K18_RS05445 (1114325) 1114325..1114582 + 258 WP_001054376.1 YjhX family toxin Toxin
I6K18_RS05450 (1114594) 1114594..1115139 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
I6K18_RS05455 (1115195) 1115195..1115941 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
I6K18_RS05460 (1116110) 1116110..1116328 + 219 Protein_1068 hypothetical protein -
I6K18_RS05465 (1116366) 1116366..1116482 + 117 Protein_1069 VOC family protein -
I6K18_RS05470 (1116727) 1116727..1117848 + 1122 WP_000010829.1 M42 family metallopeptidase -
I6K18_RS05475 (1117845) 1117845..1118123 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
I6K18_RS05480 (1118135) 1118135..1119448 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimI / fimA / fimE / fimB 1102912..1115139 12227
flank IS/Tn - - 1111180..1112160 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T192623 WP_001054376.1 NZ_CP070007:1114325-1114582 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T192623 NZ_CP092488:c2623110-2622733 [Mycobacterium paraterrae]
GTGATCTTCTACCTCGAACGCGACGACGTTGTCGTCGGTGGAAGCATCGCTTGCGGCTTCTCGCTCGCTGTCTCCGACGA
GGGGCTGCTCCAATCGGCTGTCGCTCGGCCGCAGACGAGCGTGATGGGTGACGACGCCTACCCGACGCTCTGGGATAAGG
CTGCCGCACTGCTGCATTCGCTGGCGCGGAATTACGCATTTGTCGATGGCAACAAGCGAACCGCGTGGGCCTCGGCGTGG
GCTTTCCTTCGCCTCAACGGGATCGACCTGCCGGATGCCTACGACGTCGACTACGCGGAGCAATTGGTGCTGACGGCGGC
TGTGGGTGACGTCGACTGGCCAAAGATTGCCGACGGCCTACGCGCTCTGGCGGGATAA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT192623 WP_001309181.1 NZ_CP070007:1114594-1115139 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT192623 NZ_CP092488:c2623304-2623107 [Mycobacterium paraterrae]
GTGCCGGCGTTGAACATCCAATTCACGGACGACGAGCTGGCGCGCGTCCGCACAGCGGCCAGTCGCAATGGTAAGGCGCT
CAAGCCGTTTGCACGCGATGCGATCTTGGCCGCGGCCGACGCCCGTGCCGCGCGCGTCACCGAGGCGTTCGAGTACGTAA
CTGCTCGGTCGACTGAACTCAACCGCCGTCTCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References