222995

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 2667976..2668790 Replicon chromosome
Accession NZ_CP086334
Organism Escherichia coli strain EBJ003

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag C5N12_RS13060 Protein ID WP_001054376.1
Coordinates 2667976..2668233 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag C5N12_RS13065 Protein ID WP_001309181.1
Coordinates 2668245..2668790 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C5N12_RS13035 (2663264) 2663264..2664370 + 1107 WP_001309184.1 N-acetylneuraminate epimerase -
C5N12_RS13040 (2664435) 2664435..2665415 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
C5N12_RS13045 (2665525) 2665525..2665730 + 206 Protein_2556 HNH endonuclease -
C5N12_RS13050 (2665998) 2665998..2667238 - 1241 Protein_2557 helicase YjhR -
C5N12_RS13055 (2667354) 2667354..2667485 + 132 WP_001309182.1 hypothetical protein -
C5N12_RS13060 (2667976) 2667976..2668233 + 258 WP_001054376.1 YjhX family toxin Toxin
C5N12_RS13065 (2668245) 2668245..2668790 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
C5N12_RS13070 (2668846) 2668846..2669592 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
C5N12_RS13075 (2669761) 2669761..2669979 + 219 Protein_2562 hypothetical protein -
C5N12_RS13080 (2670017) 2670017..2670133 + 117 Protein_2563 VOC family protein -
C5N12_RS13085 (2670378) 2670378..2671499 + 1122 WP_000010829.1 M42 family metallopeptidase -
C5N12_RS13090 (2671496) 2671496..2671774 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
C5N12_RS13095 (2671786) 2671786..2673099 + 1314 WP_105313517.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimI / fimA / fimE / fimB 2657763..2668790 11027


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T222995 WP_001054376.1 NZ_CP086334:2667976-2668233 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T222995 NZ_CP118272:1879647-1879749 [Klebsiella quasipneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT222995 WP_001309181.1 NZ_CP086334:2668245-2668790 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT222995 NZ_CP118272:c1879753-1879606 [Klebsiella quasipneumoniae]
AGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTG
GCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGTCTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References