116336

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4505130..4505944 Replicon chromosome
Accession NZ_CP034658
Organism Escherichia coli strain ATCC 98082

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag EKH78_RS21690 Protein ID WP_001054376.1
Coordinates 4505687..4505944 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag EKH78_RS21685 Protein ID WP_001309181.1
Coordinates 4505130..4505675 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EKH78_RS21655 (4500821) 4500821..4502134 - 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -
EKH78_RS21660 (4502146) 4502146..4502424 - 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
EKH78_RS21665 (4502421) 4502421..4503542 - 1122 WP_000010829.1 M42 family metallopeptidase -
EKH78_RS21670 (4503787) 4503787..4503903 - 117 Protein_4273 VOC family protein -
EKH78_RS21675 (4503941) 4503941..4504159 - 219 Protein_4274 hypothetical protein -
EKH78_RS21680 (4504328) 4504328..4505074 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
EKH78_RS21685 (4505130) 4505130..4505675 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
EKH78_RS21690 (4505687) 4505687..4505944 - 258 WP_001054376.1 YjhX family toxin Toxin
EKH78_RS24805 (4506435) 4506435..4506566 - 132 WP_001309182.1 hypothetical protein -
EKH78_RS21700 (4506682) 4506682..4507922 + 1241 Protein_4279 helicase YjhR -
EKH78_RS24810 (4508190) 4508190..4508395 - 206 Protein_4280 HNH endonuclease -
EKH78_RS21705 (4508505) 4508505..4509485 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
EKH78_RS21710 (4509550) 4509550..4510656 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimB / fimE / fimA / fimI / fimC 4505130..4516920 11790


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T116336 WP_001054376.1 NZ_CP034658:c4505944-4505687 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T116336 NZ_CP034658:c4505944-4505687 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT116336 WP_001309181.1 NZ_CP034658:c4505675-4505130 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT116336 NZ_CP034658:c4505675-4505130 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References