Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 3443589..3444403 Replicon chromosome
Accession NZ_LR890410
Organism Escherichia coli isolate MSB2_1A-sc-2280429

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag JMW04_RS16350 Protein ID WP_001054376.1
Coordinates 3444146..3444403 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID S1NWL7
Locus tag JMW04_RS16345 Protein ID WP_001540600.1
Coordinates 3443589..3444134 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW04_RS16315 3439280..3440593 - 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -
JMW04_RS16320 3440605..3440883 - 279 WP_000722973.1 PTS sugar transporter subunit IIB -
JMW04_RS16325 3440880..3442001 - 1122 WP_000010829.1 M42 family metallopeptidase -
JMW04_RS16330 3442246..3442362 - 117 Protein_3186 VOC family protein -
JMW04_RS16335 3442400..3442618 - 219 Protein_3187 hypothetical protein -
JMW04_RS16340 3442787..3443533 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
JMW04_RS16345 3443589..3444134 - 546 WP_001540600.1 N-acetyltransferase Antitoxin
JMW04_RS16350 3444146..3444403 - 258 WP_001054376.1 hypothetical protein Toxin
JMW04_RS16355 3444780..3445025 - 246 Protein_3191 GNAT family N-acetyltransferase -
JMW04_RS16360 3445141..3446381 + 1241 Protein_3192 DNA helicase -
JMW04_RS16365 3446964..3447944 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
JMW04_RS16370 3448009..3449115 - 1107 WP_001774143.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimB / fimE / fimA / fimI / fimC 3443589..3455379 11790


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T290924 WP_001054376.1 NZ_LR890410:c3444403-3444146 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19926.87 Da        Isoelectric Point: 6.3277

>AT290924 WP_001540600.1 NZ_LR890410:c3444134-3443589 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFGKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB S1NWL7

References