50699

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 365263..366077 Replicon chromosome
Accession NZ_CP010140
Organism Escherichia coli strain D3

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag RG36_RS02005 Protein ID WP_001054376.1
Coordinates 365820..366077 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag RG36_RS02000 Protein ID WP_001309181.1
Coordinates 365263..365808 (-) Length 182 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RG36_RS01975 360954..362267 - 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -
RG36_RS01980 362279..362557 - 279 WP_000722973.1 PTS sugar transporter subunit IIB -
RG36_RS01985 362554..363675 - 1122 WP_000010829.1 M42 family metallopeptidase -
RG36_RS29420 363920..364036 - 117 Protein_342 VOC family protein -
RG36_RS28055 364074..364292 - 219 Protein_343 hypothetical protein -
RG36_RS01995 364461..365207 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
RG36_RS02000 365263..365808 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
RG36_RS02005 365820..366077 - 258 WP_001054376.1 hypothetical protein Toxin
RG36_RS28650 366454..366699 - 246 Protein_347 GNAT family N-acetyltransferase -
RG36_RS02015 366815..368055 + 1241 Protein_348 helicase YjhR -
RG36_RS02025 368638..369618 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
RG36_RS02030 369683..370789 - 1107 WP_023568191.1 N-acetylneuraminate epimerase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimB / fimE / fimA / fimI / fimC 365263..377053 11790


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-85)

Antitoxin

(18-121)


Sequences


Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T50699 WP_001054376.1 NZ_CP010140:c366077-365820 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T50699 NZ_CP010140:c366077-365820 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT50699 WP_001309181.1 NZ_CP010140:c365808-365263 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT50699 NZ_CP010140:c365808-365263 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB S1PA82


Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References