276737

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 2895058..2895872 Replicon chromosome
Accession NZ_CP122318
Organism Escherichia coli strain HT873X1

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag QCG45_RS14445 Protein ID WP_001054376.1
Coordinates 2895615..2895872 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag QCG45_RS14440 Protein ID WP_001309181.1
Coordinates 2895058..2895603 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCG45_RS14410 (2890749) 2890749..2892062 - 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -
QCG45_RS14415 (2892074) 2892074..2892352 - 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
QCG45_RS14420 (2892349) 2892349..2893470 - 1122 WP_000010829.1 M42 family metallopeptidase -
QCG45_RS14425 (2893715) 2893715..2893831 - 117 Protein_2812 VOC family protein -
QCG45_RS14430 (2893869) 2893869..2894087 - 219 Protein_2813 hypothetical protein -
QCG45_RS14435 (2894256) 2894256..2895002 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
QCG45_RS14440 (2895058) 2895058..2895603 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
QCG45_RS14445 (2895615) 2895615..2895872 - 258 WP_001054376.1 YjhX family toxin Toxin
QCG45_RS14450 (2896363) 2896363..2896494 - 132 WP_001309182.1 hypothetical protein -
QCG45_RS14455 (2896610) 2896610..2897850 + 1241 Protein_2818 helicase YjhR -
QCG45_RS14460 (2898118) 2898118..2898323 - 206 Protein_2819 HNH endonuclease -
QCG45_RS14465 (2898433) 2898433..2899413 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
QCG45_RS14470 (2899478) 2899478..2900584 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimB / fimE / fimA / fimI / fimC 2895058..2906848 11790


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T276737 WP_001054376.1 NZ_CP122318:c2895872-2895615 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT276737 WP_001309181.1 NZ_CP122318:c2895603-2895058 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References