Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 574497..575311 Replicon chromosome
Accession NZ_CP116194
Organism Escherichia coli strain DETEC-E1005

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag PIB63_RS02770 Protein ID WP_001054376.1
Coordinates 575054..575311 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID S1NWL7
Locus tag PIB63_RS02765 Protein ID WP_001540600.1
Coordinates 574497..575042 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIB63_RS02735 (570188) 570188..571501 - 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -
PIB63_RS02740 (571513) 571513..571791 - 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
PIB63_RS02745 (571788) 571788..572909 - 1122 WP_000010829.1 M42 family metallopeptidase -
PIB63_RS02750 (573154) 573154..573270 - 117 Protein_532 VOC family protein -
PIB63_RS02755 (573308) 573308..573526 - 219 Protein_533 hypothetical protein -
PIB63_RS02760 (573695) 573695..574441 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
PIB63_RS02765 (574497) 574497..575042 - 546 WP_001540600.1 N-acetyltransferase Antitoxin
PIB63_RS02770 (575054) 575054..575311 - 258 WP_001054376.1 YjhX family toxin Toxin
PIB63_RS02775 (575802) 575802..575933 - 132 WP_001309182.1 hypothetical protein -
PIB63_RS02780 (576049) 576049..577289 + 1241 Protein_538 helicase YjhR -
PIB63_RS02785 (577557) 577557..577762 - 206 Protein_539 HNH endonuclease -
PIB63_RS02790 (577872) 577872..578852 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
PIB63_RS02795 (578917) 578917..580023 - 1107 WP_001774143.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimB / fimE / fimA / fimI / fimC 574497..586287 11790


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T268388 WP_001054376.1 NZ_CP116194:c575311-575054 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19926.87 Da        Isoelectric Point: 6.3277

>AT268388 WP_001540600.1 NZ_CP116194:c575042-574497 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFGKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB S1NWL7

References