264699

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 3468430..3469244 Replicon chromosome
Accession NZ_CP110996
Organism Escherichia coli strain XYEH3783

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag ORI30_RS16725 Protein ID WP_001054376.1
Coordinates 3468987..3469244 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID S1NWL7
Locus tag ORI30_RS16720 Protein ID WP_001540600.1
Coordinates 3468430..3468975 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORI30_RS16690 (3464121) 3464121..3465434 - 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -
ORI30_RS16695 (3465446) 3465446..3465724 - 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
ORI30_RS16700 (3465721) 3465721..3466842 - 1122 WP_000010829.1 M42 family metallopeptidase -
ORI30_RS16705 (3467087) 3467087..3467203 - 117 Protein_3260 VOC family protein -
ORI30_RS16710 (3467241) 3467241..3467459 - 219 Protein_3261 hypothetical protein -
ORI30_RS16715 (3467628) 3467628..3468374 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
ORI30_RS16720 (3468430) 3468430..3468975 - 546 WP_001540600.1 N-acetyltransferase Antitoxin
ORI30_RS16725 (3468987) 3468987..3469244 - 258 WP_001054376.1 YjhX family toxin Toxin
ORI30_RS16730 (3469735) 3469735..3469866 - 132 WP_001309182.1 hypothetical protein -
ORI30_RS16735 (3469982) 3469982..3471222 + 1241 Protein_3266 helicase YjhR -
ORI30_RS16740 (3471490) 3471490..3471695 - 206 Protein_3267 HNH endonuclease -
ORI30_RS16745 (3471805) 3471805..3472785 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
ORI30_RS16750 (3472850) 3472850..3473956 - 1107 WP_001774143.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimB / fimE / fimA / fimI / fimC 3468430..3480220 11790


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T264699 WP_001054376.1 NZ_CP110996:c3469244-3468987 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19926.87 Da        Isoelectric Point: 6.3277

>AT264699 WP_001540600.1 NZ_CP110996:c3468975-3468430 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFGKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB S1NWL7

References