242177

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 1346974..1347788 Replicon chromosome
Accession NZ_CP095518
Organism Escherichia coli strain GN02350

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag MW405_RS06340 Protein ID WP_001054376.1
Coordinates 1346974..1347231 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag MW405_RS06345 Protein ID WP_001309181.1
Coordinates 1347243..1347788 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MW405_RS06315 (1342262) 1342262..1343368 + 1107 WP_001309184.1 N-acetylneuraminate epimerase -
MW405_RS06320 (1343433) 1343433..1344413 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
MW405_RS06325 (1344523) 1344523..1344728 + 206 Protein_1234 HNH endonuclease -
MW405_RS06330 (1344996) 1344996..1346236 - 1241 Protein_1235 helicase YjhR -
MW405_RS06335 (1346352) 1346352..1346483 + 132 WP_001309182.1 hypothetical protein -
MW405_RS06340 (1346974) 1346974..1347231 + 258 WP_001054376.1 YjhX family toxin Toxin
MW405_RS06345 (1347243) 1347243..1347788 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
MW405_RS06350 (1347844) 1347844..1348590 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
MW405_RS06355 (1348759) 1348759..1348977 + 219 Protein_1240 hypothetical protein -
MW405_RS06360 (1349015) 1349015..1349131 + 117 Protein_1241 VOC family protein -
MW405_RS06365 (1349376) 1349376..1350497 + 1122 WP_000010830.1 M42 family metallopeptidase -
MW405_RS06370 (1350494) 1350494..1350772 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
MW405_RS06375 (1350784) 1350784..1352097 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimI / fimA / fimE / fimB 1336759..1347788 11029


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T242177 WP_001054376.1 NZ_CP095518:1346974-1347231 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T242177 NZ_OW052188:3480365-3480682 [Mycobacterium tuberculosis]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT242177 WP_001309181.1 NZ_CP095518:1347243-1347788 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT242177 NZ_OW052188:3480153-3480368 [Mycobacterium tuberculosis]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References