153481

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 2319219..2320033 Replicon chromosome
Accession NZ_CP050998
Organism Escherichia coli O39:NM str. F8704-2

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag P411_RS12035 Protein ID WP_001054376.1
Coordinates 2319219..2319476 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID B7MMJ3
Locus tag P411_RS12040 Protein ID WP_001338189.1
Coordinates 2319488..2320033 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P411_RS12015 (2314507) 2314507..2315613 + 1107 WP_001299704.1 N-acetylneuraminate epimerase -
P411_RS12020 (2315678) 2315678..2316658 + 981 WP_000991455.1 sialate O-acetylesterase -
P411_RS28340 (2316768) 2316768..2316973 + 206 Protein_2289 HNH endonuclease -
P411_RS12025 (2317241) 2317241..2318481 - 1241 Protein_2290 helicase YjhR -
P411_RS28345 (2318597) 2318597..2318728 + 132 WP_001309182.1 hypothetical protein -
P411_RS12035 (2319219) 2319219..2319476 + 258 WP_001054376.1 YjhX family toxin Toxin
P411_RS12040 (2319488) 2319488..2320033 + 546 WP_001338189.1 N-acetyltransferase Antitoxin
P411_RS12045 (2320089) 2320089..2320835 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
P411_RS12050 (2321004) 2321004..2321222 + 219 Protein_2295 hypothetical protein -
P411_RS12055 (2321260) 2321260..2321376 + 117 Protein_2296 VOC family protein -
P411_RS12060 (2321621) 2321621..2322742 + 1122 WP_000010829.1 M42 family metallopeptidase -
P411_RS12065 (2322739) 2322739..2323017 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
P411_RS12070 (2323029) 2323029..2324342 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimC / fimI / fimA / fimE / fimB 2308242..2320033 11791


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T153481 WP_001054376.1 NZ_CP050998:2319219-2319476 [Escherichia coli O39:NM str. F8704-2]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T153481 NZ_CP066923:c4644317-4644165 [Xanthomonas campestris pv. incanae]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTCTCGGCCGGCATGATGACTGGCTGTAACACCATGGCTGGTGC
CGGAAAGGACATGCAGGGTGCGGGTGACAAGGTCGAGAAGACCGCCGACAAATGCAGCGACGGTAAGTGCTGA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19986.92 Da        Isoelectric Point: 6.3277

>AT153481 WP_001338189.1 NZ_CP050998:2319488-2320033 [Escherichia coli O39:NM str. F8704-2]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVTSLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT153481 NZ_CP066923:c4644088-4643954 [Xanthomonas campestris pv. incanae]
ATGAAGCGTGCAATTGCATTGTTGGTGCTGTCGATGTTGTCGGTTGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCCGCGCGCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB A0A0E2KXJ3

References