Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4394596..4395410 Replicon chromosome
Accession NZ_CP097716
Organism Escherichia coli strain MS1718

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag M9O77_RS20945 Protein ID WP_001054376.1
Coordinates 4394596..4394853 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag M9O77_RS20950 Protein ID WP_001309181.1
Coordinates 4394865..4395410 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9O77_RS20920 (4389856) 4389856..4390836 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
M9O77_RS20925 (4390946) 4390946..4391151 + 206 Protein_4100 HNH endonuclease -
M9O77_RS20930 (4391451) 4391451..4392431 - 981 WP_000019400.1 IS5-like element IS5 family transposase -
M9O77_RS20935 (4392618) 4392618..4393858 - 1241 Protein_4102 helicase YjhR -
M9O77_RS20940 (4393974) 4393974..4394105 + 132 WP_001309182.1 hypothetical protein -
M9O77_RS20945 (4394596) 4394596..4394853 + 258 WP_001054376.1 YjhX family toxin Toxin
M9O77_RS20950 (4394865) 4394865..4395410 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
M9O77_RS20955 (4395466) 4395466..4396212 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
M9O77_RS20960 (4396381) 4396381..4396599 + 219 Protein_4107 hypothetical protein -
M9O77_RS20965 (4396637) 4396637..4396753 + 117 Protein_4108 VOC family protein -
M9O77_RS20970 (4396998) 4396998..4398119 + 1122 WP_000010829.1 M42 family metallopeptidase -
M9O77_RS20975 (4398116) 4398116..4398394 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
M9O77_RS20980 (4398406) 4398406..4399719 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimB 4385891..4395410 9519
flank IS/Tn - - 4391451..4392431 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T246106 WP_001054376.1 NZ_CP097716:4394596-4394853 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT246106 WP_001309181.1 NZ_CP097716:4394865-4395410 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References