170774

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ralRA/-
Location 1398006..1398377 Replicon chromosome
Accession NZ_CP060708
Organism Escherichia coli strain MFDpir

Toxin (Protein)


Gene name ralR Uniprot ID F4VC37
Locus tag H9446_RS06860 Protein ID WP_001317028.1
Coordinates 1398183..1398377 (-) Length 65 a.a.

Antitoxin (RNA)


Gene name ralA
Locus tag -
Coordinates 1398006..1398184 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9446_RS06830 1393097..1394128 - 1032 WP_000559900.1 low conductance mechanosensitive channel YnaI -
H9446_RS06835 1394282..1395298 + 1017 WP_010723085.1 IS5-like element IS5 family transposase -
H9446_RS06840 1395586..1396398 - 813 Protein_1329 tRNA 2-thiocytidine(32) synthetase TtcA -
H9446_RS06845 1396450..1397685 - 1236 WP_000040852.1 site-specific integrase -
H9446_RS06850 1397687..1397902 - 216 WP_000079604.1 excisionase XisR -
H9446_RS06855 1397981..1398190 - 210 WP_000276809.1 double-strand break reduction protein RcbA -
- 1398006..1398184 + 179 NuclAT_0 - Antitoxin
- 1398006..1398184 + 179 NuclAT_0 - Antitoxin
- 1398006..1398184 + 179 NuclAT_0 - Antitoxin
- 1398006..1398184 + 179 NuclAT_0 - Antitoxin
H9446_RS06860 1398183..1398377 - 195 WP_001317028.1 type I toxin-antitoxin system endodeoxyribonuclease toxin RalR Toxin
H9446_RS06865 1398434..1399243 - 810 WP_000166319.1 recombination protein RecT -
H9446_RS06870 1399236..1401836 - 2601 WP_000105143.1 exodeoxyribonuclease VIII -
H9446_RS06875 1401938..1402213 - 276 WP_000632297.1 protein RacC -
H9446_RS06880 1402288..1402458 - 171 WP_001352098.1 conserved protein, Rac prophage -
H9446_RS06885 1402458..1402679 - 222 WP_000560225.1 killing protein KilR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1396450..1418124 21674
flank IS/Tn - - 1394318..1395298 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endodeoxyribonuclease toxin RalR

(6-54)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7018.89 Da        Isoelectric Point: 8.9538

>T170774 WP_001317028.1 NZ_CP060708:c1398377-1398183 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Download         Length: 195 bp

>T170774 NZ_CP077702:3424984-3425202 [Salmonella enterica subsp. enterica]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 179 bp

>AT170774 NZ_CP060708:1398006-1398184 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L6LHV7

Antitoxin

Download structure file

References