Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ralRA/-
Location 1393012..1393383 Replicon chromosome
Accession NZ_CP054665
Organism Escherichia coli strain IGC_EcoliInv_1.1

Toxin (Protein)


Gene name ralR Uniprot ID -
Locus tag HUR94_RS06915 Protein ID WP_073972148.1
Coordinates 1393189..1393383 (-) Length 65 a.a.

Antitoxin (RNA)


Gene name ralA
Locus tag -
Coordinates 1393012..1393190 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUR94_RS06885 (1388103) 1388103..1389134 - 1032 WP_000559900.1 low conductance mechanosensitive channel YnaI -
HUR94_RS06890 (1389324) 1389324..1390304 + 981 WP_000019403.1 IS5-like element IS5 family transposase -
HUR94_RS06895 (1390592) 1390592..1391404 - 813 Protein_1338 tRNA 2-thiocytidine(32) synthetase TtcA -
HUR94_RS06900 (1391456) 1391456..1392691 - 1236 WP_000040854.1 site-specific integrase -
HUR94_RS06905 (1392693) 1392693..1392908 - 216 WP_000079604.1 excisionase XisR -
- (1393012) 1393012..1393190 + 179 NuclAT_0 - Antitoxin
- (1393012) 1393012..1393190 + 179 NuclAT_0 - Antitoxin
- (1393012) 1393012..1393190 + 179 NuclAT_0 - Antitoxin
- (1393012) 1393012..1393190 + 179 NuclAT_0 - Antitoxin
HUR94_RS06910 (1393008) 1393008..1393196 - 189 WP_061892272.1 DUF1187 family protein -
HUR94_RS06915 (1393189) 1393189..1393383 - 195 WP_073972148.1 type I toxin-antitoxin system endodeoxyribonuclease toxin RalR Toxin
HUR94_RS06920 (1393416) 1393416..1394096 - 681 WP_063119825.1 YqaJ viral recombinase family protein -
HUR94_RS06925 (1394093) 1394093..1394878 - 786 WP_063119826.1 phage recombination protein Bet -
HUR94_RS06930 (1394884) 1394884..1395180 - 297 WP_061892273.1 host-nuclease inhibitor Gam family protein -
HUR94_RS06935 (1395338) 1395338..1397131 - 1794 Protein_1346 exonuclease VIII -
HUR94_RS06940 (1397231) 1397231..1397506 - 276 WP_005049830.1 hypothetical protein -
HUR94_RS06945 (1397581) 1397581..1397862 - 282 WP_061892274.1 YdaE family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1384145..1437913 53768
flank IS/Tn - - 1389324..1390304 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endodeoxyribonuclease toxin RalR

(6-54)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 6943.89 Da        Isoelectric Point: 9.2887

>T160040 WP_073972148.1 NZ_CP054665:c1393383-1393189 [Escherichia coli]
VLYTKVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Download         Length: 195 bp

>T160040 NZ_CP070284:279141-279668 [Escherichia albertii]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTGGTTCGTCAACATCGCAATAAAATTTTGCGAGCGTATATCCTTTGCCGCAACACTC
CAGAACGTCAGGTCCTGGGATATTACACATTATCCGGCAGTTGTTTTGAACGAGCCGCACTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTCACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCATTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCTCTGAATGAAAAAGCCCATACGTTTTATCAGTCGCTGGGCTTTATCCCGTTGGTTGGAGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATTGAACTGCTTTTTACACAGAGCGATTAA

Antitoxin


Download         Length: 179 bp

>AT160040 NZ_CP054665:1393012-1393190 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTATCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References