Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4705534..4706348 Replicon chromosome
Accession NZ_CP095510
Organism Escherichia coli strain GN02270

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag MW401_RS22755 Protein ID WP_001054376.1
Coordinates 4705534..4705791 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag MW401_RS22760 Protein ID WP_001309181.1
Coordinates 4705803..4706348 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MW401_RS22730 (4700794) 4700794..4701774 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
MW401_RS22735 (4701884) 4701884..4702089 + 206 Protein_4446 HNH endonuclease -
MW401_RS22740 (4702389) 4702389..4703369 - 981 WP_000019400.1 IS5-like element IS5 family transposase -
MW401_RS22745 (4703556) 4703556..4704796 - 1241 Protein_4448 helicase YjhR -
MW401_RS22750 (4704912) 4704912..4705043 + 132 WP_001309182.1 hypothetical protein -
MW401_RS22755 (4705534) 4705534..4705791 + 258 WP_001054376.1 YjhX family toxin Toxin
MW401_RS22760 (4705803) 4705803..4706348 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
MW401_RS22765 (4706404) 4706404..4707150 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
MW401_RS22770 (4707319) 4707319..4707537 + 219 Protein_4453 hypothetical protein -
MW401_RS22775 (4707575) 4707575..4707691 + 117 Protein_4454 VOC family protein -
MW401_RS22780 (4707936) 4707936..4709057 + 1122 WP_000010829.1 M42 family metallopeptidase -
MW401_RS22785 (4709054) 4709054..4709332 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
MW401_RS22790 (4709344) 4709344..4710657 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimB 4696829..4714572 17743
flank IS/Tn - - 4702389..4703369 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T242127 WP_001054376.1 NZ_CP095510:4705534-4705791 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T242127 NZ_OV996158:2963415-2963681 [Enterococcus mundtii]
ATGAGCTACTCGGTAAGAACAACTCCTACCTTCGATAGGCAAATAAGAAAACTAGACAAATTCGAAGCAACAACTATATT
AAGATGGTTACATAAACAGATCGAAGGCACAAAAAATCCTAGATATACAGGTAAGCCACTTGTGGGGAACTACGCAGGTA
AATGGCGATACAGAATAGGAAATTATCGCGTCATTACAAAGATTGATGATGAAAAGTTGATTGTTTTAGCATTAGAAGTA
GGACATAGAAAAAATATATATCTATAG

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT242127 WP_001309181.1 NZ_CP095510:4705803-4706348 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT242127 NZ_OV996158:2963185-2963418 [Enterococcus mundtii]
ATGGCAACAATTACAGTTCGTGTGACAGAAGATGAGAAAAAATTTTTGGATGAAATGGCTAAGTTTGAAGGAAAGAGTCT
CTCTGAATTACTTAAAACAAAAACATTAGATGCTTTAGAAGATGCGTATGATGCAAAGATAGGAGATTTAGCCTATGAAG
AGTATTTGAAAGATAAAAAATCAAATGATTTATCTGTTCTTTTAGAGGAGTATGATATAGGTGAAAAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References