Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4438407..4439221 Replicon chromosome
Accession NZ_LR890405
Organism Escherichia coli isolate MSB1_7C-sc-2280317

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag JMW09_RS21280 Protein ID WP_001054376.1
Coordinates 4438407..4438664 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag JMW09_RS21285 Protein ID WP_001309181.1
Coordinates 4438676..4439221 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW09_RS21260 4433667..4434647 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
JMW09_RS21265 4435262..4436278 - 1017 WP_001322394.1 IS5-like element IS5 family transposase -
JMW09_RS21270 4436429..4437669 - 1241 Protein_4165 DNA helicase -
JMW09_RS21275 4437785..4438030 + 246 Protein_4166 GNAT family N-acetyltransferase -
JMW09_RS21280 4438407..4438664 + 258 WP_001054376.1 hypothetical protein Toxin
JMW09_RS21285 4438676..4439221 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
JMW09_RS21290 4439277..4440023 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
JMW09_RS21295 4440192..4440410 + 219 Protein_4170 hypothetical protein -
JMW09_RS21300 4440448..4440564 + 117 Protein_4171 VOC family protein -
JMW09_RS21305 4440809..4441930 + 1122 WP_000010829.1 M42 family metallopeptidase -
JMW09_RS21310 4441927..4442205 + 279 WP_000722973.1 PTS sugar transporter subunit IIB -
JMW09_RS21315 4442217..4443530 + 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimB 4429702..4447445 17743
flank IS/Tn - - 4435262..4436242 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T290904 WP_001054376.1 NZ_LR890405:4438407-4438664 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT290904 WP_001309181.1 NZ_LR890405:4438676-4439221 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References