269792

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 1105991..1106658 Replicon chromosome
Accession NZ_CP117010
Organism Escherichia coli strain MLI110

Toxin (Protein)


Gene name ypjF Uniprot ID Q46953
Locus tag NL413_RS06025 Protein ID WP_001094400.1
Coordinates 1105991..1106320 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID P52141
Locus tag NL413_RS06030 Protein ID WP_000072690.1
Coordinates 1106341..1106658 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL413_RS06020 (1101909) 1101909..1105631 + 3723 Protein_1045 adhesin-like autotransporter YpjA/EhaD -
NL413_RS06025 (1105991) 1105991..1106320 - 330 WP_001094400.1 type IV toxin-antitoxin system toxin YpjF Toxin
NL413_RS06030 (1106341) 1106341..1106658 - 318 WP_000072690.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NL413_RS06035 (1106696) 1106696..1106896 - 201 WP_001395452.1 DUF987 domain-containing protein -
NL413_RS06040 (1106905) 1106905..1107387 - 483 WP_001407480.1 RadC family protein -
NL413_RS06045 (1107396) 1107396..1107854 - 459 WP_000211841.1 antirestriction protein -
NL413_RS06050 (1107957) 1107957..1108141 - 185 Protein_1051 DUF905 family protein -
NL413_RS06055 (1108752) 1108752..1110455 - 1704 WP_000896263.1 protein YfjW -
NL413_RS06060 (1110597) 1110597..1111606 + 1010 Protein_1053 arsenic transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1095150..1130681 35531
flank IS/Tn - - 1100798..1101778 980
- inside Prophage - luxS 1051699..1130076 78377


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12308.21 Da        Isoelectric Point: 7.2761

>T269792 WP_001094400.1 NZ_CP117010:c1106320-1105991 [Escherichia coli]
MNTLPATISQAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVEKYELVRIDHRGF
SWQQQSPYISVVDILRARRSTGLLKTNVK

Download         Length: 330 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11737.27 Da        Isoelectric Point: 6.4630

>AT269792 WP_000072690.1 NZ_CP117010:c1106658-1106341 [Escherichia coli]
MSNTTWGLQRDITPRLGARLVQEGNQLHYLADRASITGKFSDAECPKLDVVFPHFISQIESMLTTGELNPRHAQCVTLYH
NGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A373F4I3

Antitoxin

Source ID Structure
AlphaFold DB P52141

References