Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4439680..4440494 Replicon chromosome
Accession NZ_CP082827
Organism Escherichia coli strain SCAID WND2-2021 (3/145)

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag K8B73_RS21355 Protein ID WP_001054376.1
Coordinates 4439680..4439937 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag K8B73_RS21360 Protein ID WP_001309181.1
Coordinates 4439949..4440494 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8B73_RS21335 (4434940) 4434940..4435920 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
K8B73_RS26425 (4436030) 4436030..4436235 + 206 Protein_4194 HNH endonuclease -
K8B73_RS21340 (4436535) 4436535..4437515 - 981 WP_000019400.1 IS5-like element IS5 family transposase -
K8B73_RS21345 (4437702) 4437702..4438942 - 1241 Protein_4196 helicase YjhR -
K8B73_RS26430 (4439058) 4439058..4439189 + 132 WP_001309182.1 hypothetical protein -
K8B73_RS21355 (4439680) 4439680..4439937 + 258 WP_001054376.1 YjhX family toxin Toxin
K8B73_RS21360 (4439949) 4439949..4440494 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
K8B73_RS21365 (4440550) 4440550..4441296 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
K8B73_RS21370 (4441465) 4441465..4441683 + 219 Protein_4201 hypothetical protein -
K8B73_RS21375 (4441721) 4441721..4441837 + 117 Protein_4202 VOC family protein -
K8B73_RS21380 (4442082) 4442082..4443203 + 1122 WP_000010829.1 M42 family metallopeptidase -
K8B73_RS21385 (4443200) 4443200..4443478 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
K8B73_RS21390 (4443490) 4443490..4444803 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimB 4430975..4448718 17743
flank IS/Tn - - 4436535..4437515 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T215294 WP_001054376.1 NZ_CP082827:4439680-4439937 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T215294 NZ_CP110620:c732251-731937 [Pasteurella multocida]
ATGCTCGATATAATTGAAACAACAGTATTTAATAAATGGCTTAAAGAGCTAAAGGATTTGTCGGCTAAAGCGGCTATTCT
TGCACGTATTAGTCGCGCTAAAAGTGGTAATTTTGGTGACCATAAATCAGTTGGTGATGGTTTGTATGAAATGCGAATAA
TGAAAGGAGCTGGTTATAGGGTTTATTATGCACAATACAAAGATGTAACCTATTTGCTAATTTGTGGCGGTGATAAATCT
ACTCAGAAAGCAGATATCGCTAAAGCAAAAGCATTATGGGAAGAGATTAAGCAGAAAGAGGAGATAAATGTATGA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT215294 WP_001309181.1 NZ_CP082827:4439949-4440494 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT215294 NZ_CP110620:c731940-731650 [Pasteurella multocida]
ATGAGTAAAAAAGTAGAATTAAAACCATTTGATATTGCTGAATACCTAGATAGTGAAGAAATGATTGCGGCATATTTAAG
TGAAATTTTAGAAACAGGTGACACTAATGAATTTATTTCTGCGCTAGGTGATGTCGCAAGAGCGAGAGGAATGACGGAGT
TAGCGGCAAAAACAGGATTAGGAAGAGAAAGTCTCTATAAAACATTATCACACGGAAGTAAGCCGCGTTTTGATACTATA
ATGAAAATTACGCAAGCACTAGGTATTAAACTTGTCCCAACGCATATCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References