176753

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2306175..2306701 Replicon chromosome
Accession NZ_CP062826
Organism Escherichia coli strain Res13-Lact-PER12-33-A

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag IMQ30_RS11145 Protein ID WP_000323025.1
Coordinates 2306414..2306701 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag IMQ30_RS11140 Protein ID WP_000534858.1
Coordinates 2306175..2306414 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMQ30_RS11115 2301509..2301865 + 357 WP_001374839.1 class I SAM-dependent methyltransferase -
IMQ30_RS11120 2302476..2302763 + 288 Protein_2173 hypothetical protein -
IMQ30_RS11125 2303532..2304873 + 1342 Protein_2174 ISNCY family transposase -
IMQ30_RS11130 2305310..2305642 - 333 WP_001317460.1 FlxA-like family protein -
IMQ30_RS11135 2305845..2306150 - 306 WP_001326990.1 hypothetical protein -
IMQ30_RS11140 2306175..2306414 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
IMQ30_RS11145 2306414..2306701 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
IMQ30_RS11150 2306773..2306928 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
IMQ30_RS11155 2307145..2307396 + 252 WP_000980994.1 hypothetical protein -
IMQ30_RS11160 2307463..2307741 + 279 WP_012304870.1 hypothetical protein -
IMQ30_RS11165 2307743..2308792 + 1050 WP_001265198.1 DUF968 domain-containing protein -
IMQ30_RS11170 2308806..2309558 + 753 WP_001047135.1 antitermination protein -
IMQ30_RS11175 2309836..2309925 - 90 WP_120795389.1 hypothetical protein -
IMQ30_RS11180 2309980..2310192 - 213 WP_000087756.1 cold shock-like protein CspF -
IMQ30_RS11185 2310462..2311478 + 1017 WP_001322394.1 IS5-like element IS5 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2289219..2324628 35409
flank IS/Tn - - 2310498..2311478 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T176753 WP_000323025.1 NZ_CP062826:2306414-2306701 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T176753 NZ_CP082926:c2927004-2926750 [Shewanella inventionis]
ATGAACAAAAAACATTTAAGAACGTTAGCGGCTATTTTTGCTAGACCTGTCAGCGGTTCTATCAAGTGGTCTGATATTGA
AGCGCTGTTTATTGCTCTAGGGGCAGACATAGAGGAACGTGAGGGTTCTCGAATTGGTGTGGTGCTGTTTGGTGAAGTTC
AGGTATATCACCGCCCACATCCTCATAAAGAAACTGACAAAGGCGCAGTGGTAAGCGTCAAAAAATGGTTAGAAAGAAAC
GGGGTAAAAGCATGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT176753 WP_000534858.1 NZ_CP062826:2306175-2306414 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT176753 NZ_CP082926:c2926753-2926412 [Shewanella inventionis]
ATGAAAAATCTAATGATGATCAACGGGGTAAAAGCCTTTATTAATTTTGATCCAGACGCTGAAACATTCCGTGGAGAGTT
CGTTGGGTTAAACGGCGGCGCGGATTTCTACGGTGAAAGCATCAATCAATTGGAAGCCGAGGGCGCGAAGTCATTAAGCG
TTTTTTTAGAGATGTGTCAGGAGCGTGGCATTGAGCCTTATAAAAACTTCTCTGGCAAATTCAACGTTCGGATCTCGCCA
GAGGTTCACGCTCGACTGAATGAAATAGCGCTATCGCAAAGCATTAGTTTGAATGCTGCGGTAGAAAATGCAGTCAATGA
CTACATTGCACATTCAGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References