Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4402062..4402876 Replicon chromosome
Accession NZ_CP051694
Organism Escherichia coli strain SCU-313

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag HHJ46_RS21160 Protein ID WP_001054376.1
Coordinates 4402062..4402319 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag HHJ46_RS21165 Protein ID WP_001309181.1
Coordinates 4402331..4402876 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ46_RS21140 4397322..4398302 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
HHJ46_RS21145 4398917..4399933 - 1017 WP_001322394.1 IS5-like element IS5 family transposase -
HHJ46_RS21150 4400084..4401324 - 1241 Protein_4132 helicase YjhR -
HHJ46_RS21155 4401440..4401685 + 246 Protein_4133 GNAT family N-acetyltransferase -
HHJ46_RS21160 4402062..4402319 + 258 WP_001054376.1 hypothetical protein Toxin
HHJ46_RS21165 4402331..4402876 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
HHJ46_RS21170 4402932..4403678 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
HHJ46_RS21175 4403847..4404065 + 219 Protein_4137 hypothetical protein -
HHJ46_RS25535 4404103..4404219 + 117 Protein_4138 VOC family protein -
HHJ46_RS21180 4404464..4405585 + 1122 WP_000010829.1 M42 family metallopeptidase -
HHJ46_RS21185 4405582..4405860 + 279 WP_000722973.1 PTS sugar transporter subunit IIB -
HHJ46_RS21190 4405872..4407185 + 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimI / fimA / fimE / fimB 4390649..4411740 21091
flank IS/Tn - - 4398917..4399897 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T154828 WP_001054376.1 NZ_CP051694:4402062-4402319 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T154828 NZ_CP068283:c468061-467843 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT154828 WP_001309181.1 NZ_CP051694:4402331-4402876 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT154828 NZ_CP068283:c468461-468087 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References