192849

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4379809..4380623 Replicon chromosome
Accession NZ_CP070048
Organism Escherichia coli strain FDAARGOS_1290

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag I6K20_RS21185 Protein ID WP_001054376.1
Coordinates 4380366..4380623 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag I6K20_RS21180 Protein ID WP_001309181.1
Coordinates 4379809..4380354 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K20_RS21150 (4375500) 4375500..4376813 - 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -
I6K20_RS21155 (4376825) 4376825..4377103 - 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
I6K20_RS21160 (4377100) 4377100..4378221 - 1122 WP_000010829.1 M42 family metallopeptidase -
I6K20_RS21165 (4378466) 4378466..4378582 - 117 Protein_4170 VOC family protein -
I6K20_RS21170 (4378620) 4378620..4378838 - 219 Protein_4171 hypothetical protein -
I6K20_RS21175 (4379007) 4379007..4379753 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
I6K20_RS21180 (4379809) 4379809..4380354 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
I6K20_RS21185 (4380366) 4380366..4380623 - 258 WP_001054376.1 YjhX family toxin Toxin
I6K20_RS25310 (4381114) 4381114..4381245 - 132 WP_001309182.1 hypothetical protein -
I6K20_RS21195 (4381361) 4381361..4382601 + 1241 Protein_4176 helicase YjhR -
I6K20_RS21200 (4382788) 4382788..4383768 + 981 WP_000019400.1 IS5-like element IS5 family transposase -
I6K20_RS25315 (4384068) 4384068..4384273 - 206 Protein_4178 HNH endonuclease -
I6K20_RS21205 (4384383) 4384383..4385363 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 4382788..4383768 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T192849 WP_001054376.1 NZ_CP070048:c4380623-4380366 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T192849 NZ_CP092563:c852468-852280 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT192849 WP_001309181.1 NZ_CP070048:c4380354-4379809 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT192849 NZ_CP092563:c852757-852497 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References