Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4424854..4425668 Replicon chromosome
Accession NZ_LR130564
Organism Escherichia coli strain MS14387 isolate MS14387

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag FVE81_RS21580 Protein ID WP_001054376.1
Coordinates 4424854..4425111 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag FVE81_RS21585 Protein ID WP_001309181.1
Coordinates 4425123..4425668 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FVE81_RS21560 4420114..4421094 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
FVE81_RS21565 4421709..4422689 - 981 WP_000019400.1 IS5-like element IS5 family transposase -
FVE81_RS21570 4422876..4424116 - 1241 Protein_4179 helicase YjhR -
FVE81_RS21575 4424232..4424477 + 246 Protein_4180 GNAT family N-acetyltransferase -
FVE81_RS21580 4424854..4425111 + 258 WP_001054376.1 hypothetical protein Toxin
FVE81_RS21585 4425123..4425668 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
FVE81_RS21590 4425724..4426470 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
FVE81_RS21595 4426639..4426857 + 219 Protein_4184 hypothetical protein -
FVE81_RS25995 4426895..4427011 + 117 Protein_4185 VOC family protein -
FVE81_RS21600 4427256..4428377 + 1122 WP_000010829.1 M42 family metallopeptidase -
FVE81_RS21605 4428374..4428652 + 279 WP_000722973.1 PTS sugar transporter subunit IIB -
FVE81_RS21610 4428664..4429977 + 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimB 4416149..4433892 17743
flank IS/Tn - - 4421709..4422689 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T286497 WP_001054376.1 NZ_LR130564:4424854-4425111 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT286497 WP_001309181.1 NZ_LR130564:4425123-4425668 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References