Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 490385..491199 Replicon chromosome
Accession NZ_CP068806
Organism Escherichia coli strain RIVM_C018576

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag JNN57_RS02345 Protein ID WP_001054376.1
Coordinates 490942..491199 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag JNN57_RS02340 Protein ID WP_001309181.1
Coordinates 490385..490930 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN57_RS02310 486076..487389 - 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -
JNN57_RS02315 487401..487679 - 279 WP_000722973.1 PTS sugar transporter subunit IIB -
JNN57_RS02320 487676..488797 - 1122 WP_000010829.1 M42 family metallopeptidase -
JNN57_RS02325 489042..489158 - 117 Protein_447 VOC family protein -
JNN57_RS02330 489196..489414 - 219 Protein_448 hypothetical protein -
JNN57_RS02335 489583..490329 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
JNN57_RS02340 490385..490930 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
JNN57_RS02345 490942..491199 - 258 WP_001054376.1 hypothetical protein Toxin
JNN57_RS02350 491576..491821 - 246 Protein_452 GNAT family N-acetyltransferase -
JNN57_RS02355 491937..493177 + 1241 Protein_453 helicase YjhR -
JNN57_RS02360 493328..494344 + 1017 WP_001322394.1 IS5-like element IS5 family transposase -
JNN57_RS02365 494959..495939 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 493364..494344 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T187998 WP_001054376.1 NZ_CP068806:c491199-490942 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T187998 NZ_CP090196:996600-997007 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATCTGCGCGTCTCCTGGCGCGCGCAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGACGCATTAATGCTCGCCAGGGAGAAATTCGCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT187998 WP_001309181.1 NZ_CP068806:c490930-490385 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT187998 NZ_CP090196:996353-996619 [Escherichia coli]
ATGGACATTAATAACAAAGCCCGCATTCACTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGAATCTTTATTCGTCTGCTGGAGTGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAGCTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References