Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4481892..4482706 Replicon chromosome
Accession NZ_AP022173
Organism Escherichia coli strain WP7-S17-ESBL-01

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag H7R26_RS21705 Protein ID WP_001054376.1
Coordinates 4481892..4482149 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag H7R26_RS21710 Protein ID WP_001309181.1
Coordinates 4482161..4482706 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7R26_RS21685 4477049..4478410 - 1362 Protein_4249 MFS transporter -
H7R26_RS21690 4478747..4479763 - 1017 WP_001322394.1 IS5-like element IS5 family transposase -
H7R26_RS21695 4479914..4481154 - 1241 Protein_4251 DNA helicase -
H7R26_RS21700 4481270..4481515 + 246 Protein_4252 GNAT family N-acetyltransferase -
H7R26_RS21705 4481892..4482149 + 258 WP_001054376.1 hypothetical protein Toxin
H7R26_RS21710 4482161..4482706 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
H7R26_RS21715 4482762..4483508 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
H7R26_RS21720 4483677..4483895 + 219 Protein_4256 hypothetical protein -
H7R26_RS25910 4483933..4484049 + 117 Protein_4257 VOC family protein -
H7R26_RS21725 4484294..4485415 + 1122 WP_000010829.1 M42 family metallopeptidase -
H7R26_RS21730 4485412..4485690 + 279 WP_000722973.1 PTS sugar transporter subunit IIB -
H7R26_RS21735 4485702..4487015 + 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 4478747..4479727 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T34852 WP_001054376.1 NZ_AP022173:4481892-4482149 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T34852 NZ_AP022173:4481892-4482149 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT34852 WP_001309181.1 NZ_AP022173:4482161-4482706 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT34852 NZ_AP022173:4482161-4482706 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References