Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 530169..530983 Replicon chromosome
Accession NZ_CP071073
Organism Escherichia coli strain 3347558

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag JY392_RS02635 Protein ID WP_001054376.1
Coordinates 530726..530983 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag JY392_RS02630 Protein ID WP_001309181.1
Coordinates 530169..530714 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JY392_RS02600 (525860) 525860..527173 - 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -
JY392_RS02605 (527185) 527185..527463 - 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
JY392_RS02610 (527460) 527460..528581 - 1122 WP_000010829.1 M42 family metallopeptidase -
JY392_RS02615 (528826) 528826..528942 - 117 Protein_509 VOC family protein -
JY392_RS02620 (528980) 528980..529198 - 219 Protein_510 hypothetical protein -
JY392_RS02625 (529367) 529367..530113 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
JY392_RS02630 (530169) 530169..530714 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
JY392_RS02635 (530726) 530726..530983 - 258 WP_001054376.1 YjhX family toxin Toxin
JY392_RS27815 (531474) 531474..531605 - 132 WP_001309182.1 hypothetical protein -
JY392_RS02645 (531721) 531721..532961 + 1241 Protein_515 helicase YjhR -
JY392_RS02650 (533148) 533148..534128 + 981 WP_000019400.1 IS5-like element IS5 family transposase -
JY392_RS27820 (534428) 534428..534633 - 206 Protein_517 HNH endonuclease -
JY392_RS02655 (534743) 534743..535723 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 533148..534128 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T195199 WP_001054376.1 NZ_CP071073:c530983-530726 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T195199 NZ_CP094352:c6976-6704 [Pseudomonas orientalis]
ATGACCTGGCGGATTGAATTTGATCCGGCAGCGGAAAAGGAACTGAAAGAACTTGGGGACGATGCAGCAAAGGACGTTCT
GAAATTTCTTGTTGGACGTATCACCAATCAAGGCGAACCACACAGTATTGGAAGCGCTCTGAAAGGCTCAGAGCTGGGCG
AGCTCTGGAAGTACCGAGTTGGAGACTATCGCATCGTTTCCAATATCCAGGACGTCACTTTAACCATTTTGGTTGTACGG
CTCAGCAGTCAGCAGAGAGGGTACAGACGATGA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT195199 WP_001309181.1 NZ_CP071073:c530714-530169 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT195199 NZ_CP094352:c7184-6960 [Pseudomonas orientalis]
ATGTTAGCTATCCGTCTTGCCCCGGAAATAGAGGAGCGCCTAGAAGCATTGGCTGCTCGTACAGGACGCACCAAGACCTT
CTATGCCCGGGAAGCCATCCTCGAGCACATTGATGACCTAGAGGATCTGTACCTAGCTGAGCAGCGATTGGGAGAGGTGC
GTGAGAACCGTAGCGAAACGATTTCACTTCAAGACGTGATCAAGTCCTATGACCTGGCGGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References