177127

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2308093..2308619 Replicon chromosome
Accession NZ_CP062883
Organism Escherichia coli strain Res13-Lact-PEA06-10

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag IMP66_RS11170 Protein ID WP_000323025.1
Coordinates 2308332..2308619 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag IMP66_RS11165 Protein ID WP_000534858.1
Coordinates 2308093..2308332 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMP66_RS11140 2303427..2303783 + 357 WP_001374839.1 class I SAM-dependent methyltransferase -
IMP66_RS11145 2304394..2304681 + 288 Protein_2178 hypothetical protein -
IMP66_RS11150 2305450..2306791 + 1342 Protein_2179 ISNCY family transposase -
IMP66_RS11155 2307228..2307560 - 333 WP_001317460.1 FlxA-like family protein -
IMP66_RS11160 2307763..2308068 - 306 WP_001326990.1 hypothetical protein -
IMP66_RS11165 2308093..2308332 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
IMP66_RS11170 2308332..2308619 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
IMP66_RS11175 2308691..2308846 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
IMP66_RS11180 2309063..2309314 + 252 WP_000980994.1 hypothetical protein -
IMP66_RS11185 2309381..2309659 + 279 WP_012304870.1 hypothetical protein -
IMP66_RS11190 2309661..2310710 + 1050 WP_001265198.1 DUF968 domain-containing protein -
IMP66_RS11195 2310724..2311476 + 753 WP_001047135.1 antitermination protein -
IMP66_RS11200 2311754..2311843 - 90 WP_120795389.1 hypothetical protein -
IMP66_RS11205 2311898..2312110 - 213 WP_000087756.1 cold shock-like protein CspF -
IMP66_RS11210 2312380..2313396 + 1017 WP_001322394.1 IS5-like element IS5 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2296169..2329196 33027
flank IS/Tn - - 2312416..2313396 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T177127 WP_000323025.1 NZ_CP062883:2308332-2308619 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T177127 NZ_CP083181:c2179311-2179129 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGACGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
CAAACACCCAACCAAAAAGGGATTAGTTACTATCCCGCATCCTAAAAAGGATTTACCAAGCGGAACTGTTAAAAGCATTT
TGAAGCAAGCGGGTCTAAAGTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT177127 WP_000534858.1 NZ_CP062883:2308093-2308332 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT177127 NZ_CP083181:c2179064-2178660 [Acinetobacter baumannii]
ATGTTGTATCCAATTGCTATCGAGAGAGGTACAGACACCGAGGCCTTTGGTGTCACCGTTCCAGATATTCCAGGATGTTT
TAGCGCAGGCGATACATTAGAGGAAGCTATCGAGAACGTTAAAGAGGCAATTTCTGGCCACTTAGAAATCCTTGCTGAAG
ATGGAGAAGAAATTCCATTAGCATCTGACTTAGCAAAATTTGTAGATGATCCAGATTATAAAGGCATGATCTGGGCTGTT
ACTGAGGTGGATGTTAGTCGTTATCTTGGTAAGCCTGAAAAAATCAACGTAACTTTACCTAGCCGTTTAATTCGCAAGAT
TGATGATAATGTAGGTAAAGATAAAAGATTTAAAACTCGTTCTGCTTTTTTGGCCGCTGGTGCTGAAAAGCTACTACATG
CTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References