Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 5051418..5052232 Replicon chromosome
Accession NZ_CP015834
Organism Escherichia coli strain MS6198

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag MS6198_RS24895 Protein ID WP_001054376.1
Coordinates 5051975..5052232 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag MS6198_RS24890 Protein ID WP_001309181.1
Coordinates 5051418..5051963 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MS6198_RS24870 5047109..5048422 - 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -
MS6198_RS24875 5048434..5048712 - 279 WP_000722973.1 PTS sugar transporter subunit IIB -
MS6198_RS24880 5048709..5049830 - 1122 WP_000010829.1 M42 family metallopeptidase -
MS6198_RS31800 5050075..5050191 - 117 Protein_4740 VOC family protein -
MS6198_RS30630 5050229..5050447 - 219 Protein_4741 hypothetical protein -
MS6198_RS24885 5050616..5051362 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
MS6198_RS24890 5051418..5051963 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
MS6198_RS24895 5051975..5052232 - 258 WP_001054376.1 hypothetical protein Toxin
MS6198_RS31280 5052609..5052854 - 246 Protein_4745 GNAT family N-acetyltransferase -
MS6198_RS24910 5052970..5054210 + 1241 Protein_4746 helicase YjhR -
MS6198_RS24915 5054397..5055377 + 981 WP_000019400.1 IS5-like element IS5 family transposase -
MS6198_RS24920 5055992..5056972 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 5054397..5055377 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T63625 WP_001054376.1 NZ_CP015834:c5052232-5051975 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T63625 NZ_CP015834:c5052232-5051975 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT63625 WP_001309181.1 NZ_CP015834:c5051963-5051418 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT63625 NZ_CP015834:c5051963-5051418 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References