Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ldrD-rdlD/Ldr(toxin)
Location 4425104..4425326 Replicon chromosome
Accession NZ_CP010444
Organism Escherichia coli K-12 strain K-12 MG1655

Toxin (Protein)


Gene name ldrD Uniprot ID S1E8T8
Locus tag SH07_RS21885 Protein ID WP_000141634.1
Coordinates 4425104..4425211 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name rdlD
Locus tag -
Coordinates 4425260..4425326 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SH07_RS21865 4420501..4421517 - 1017 WP_010723085.1 IS5-like element IS5 family transposase -
SH07_RS21870 4421582..4423153 + 1572 WP_001204931.1 cellulose biosynthesis protein BcsE -
SH07_RS21875 4423150..4423341 + 192 WP_000988308.1 cellulose biosynthesis protein BcsF -
SH07_RS21880 4423338..4425017 + 1680 WP_000191622.1 cellulose biosynthesis protein BcsG -
SH07_RS21885 4425104..4425211 - 108 WP_000141634.1 type I toxin-antitoxin system toxic polypeptide LdrD Toxin
- 4425260..4425326 + 67 - - Antitoxin
SH07_RS21895 4425687..4426958 + 1272 WP_001295225.1 transporter -
SH07_RS21900 4426988..4427992 - 1005 WP_000107012.1 dipeptide ABC transporter ATP-binding subunit DppF -
SH07_RS21905 4427989..4428972 - 984 WP_001196486.1 dipeptide ABC transporter ATP-binding protein -
SH07_RS21910 4428983..4429885 - 903 WP_000084677.1 dipeptide ABC transporter permease DppC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 4420501..4421481 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 3916.72 Da        Isoelectric Point: 9.0157

>T52690 WP_000141634.1 NZ_CP010444:c4425211-4425104 [Escherichia coli K-12]
MTFAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Download         Length: 108 bp

>T52690 NZ_CP010444:c4425211-4425104 [Escherichia coli K-12]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 67 bp

>AT52690 NZ_CP010444:4425260-4425326 [Escherichia coli K-12]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5LBJ

Antitoxin

Download structure file

References