Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4178836..4179650 Replicon chromosome
Accession NZ_CP074680
Organism Escherichia coli strain MEI008

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag KIM92_RS20200 Protein ID WP_001054376.1
Coordinates 4178836..4179093 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag KIM92_RS20205 Protein ID WP_001309181.1
Coordinates 4179105..4179650 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KIM92_RS20175 (4174096) 4174096..4175076 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
KIM92_RS20180 (4175186) 4175186..4175391 + 206 Protein_3949 HNH endonuclease -
KIM92_RS20185 (4175691) 4175691..4176671 - 981 WP_000019400.1 IS5-like element IS5 family transposase -
KIM92_RS20190 (4176858) 4176858..4178098 - 1241 Protein_3951 helicase YjhR -
KIM92_RS20195 (4178214) 4178214..4178345 + 132 WP_001309182.1 hypothetical protein -
KIM92_RS20200 (4178836) 4178836..4179093 + 258 WP_001054376.1 YjhX family toxin Toxin
KIM92_RS20205 (4179105) 4179105..4179650 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
KIM92_RS20210 (4179706) 4179706..4180452 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
KIM92_RS20215 (4180621) 4180621..4180839 + 219 Protein_3956 hypothetical protein -
KIM92_RS20220 (4180877) 4180877..4180993 + 117 Protein_3957 VOC family protein -
KIM92_RS20225 (4181238) 4181238..4182359 + 1122 WP_000010829.1 M42 family metallopeptidase -
KIM92_RS20230 (4182356) 4182356..4182634 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
KIM92_RS20235 (4182646) 4182646..4183959 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimI / fimA / fimE / fimB 4167423..4187874 20451
flank IS/Tn - - 4175691..4176671 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T202641 WP_001054376.1 NZ_CP074680:4178836-4179093 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T202641 NZ_CP099542:c3457472-3457375 [Pantoea ananatis]
GCAAGGCGAAAGCCTCTATCAATGCCAACTTTTAGCGCACGGCTCCTTGAGAGCCATTTCCCTGGACCGAATACAGGAAT
CGTGTTCGGTCTTTTTTT

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT202641 WP_001309181.1 NZ_CP074680:4179105-4179650 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT202641 NZ_CP099542:3457375-3457507 [Pantoea ananatis]
AAAAAAAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTCAAGGAGCCGTGCGCTAAAAGTTGGCATTGA
TAGAGGCTTTCGCCTTGCTTTTAAAGCGTAGGACAACGCGCCAGATTTTCCAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References