Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4150748..4151562 Replicon chromosome
Accession NZ_CP095538
Organism Escherichia coli strain GN04592

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag MW396_RS20370 Protein ID WP_001054376.1
Coordinates 4150748..4151005 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag MW396_RS20375 Protein ID WP_001309181.1
Coordinates 4151017..4151562 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MW396_RS20345 (4146008) 4146008..4146988 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
MW396_RS20350 (4147098) 4147098..4147303 + 206 Protein_3983 HNH endonuclease -
MW396_RS20355 (4147603) 4147603..4148583 - 981 WP_000019400.1 IS5-like element IS5 family transposase -
MW396_RS20360 (4148770) 4148770..4150010 - 1241 Protein_3985 helicase YjhR -
MW396_RS20365 (4150126) 4150126..4150257 + 132 WP_001309182.1 hypothetical protein -
MW396_RS20370 (4150748) 4150748..4151005 + 258 WP_001054376.1 YjhX family toxin Toxin
MW396_RS20375 (4151017) 4151017..4151562 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
MW396_RS20380 (4151618) 4151618..4152364 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
MW396_RS20385 (4152533) 4152533..4152751 + 219 Protein_3990 hypothetical protein -
MW396_RS20390 (4152789) 4152789..4152905 + 117 Protein_3991 VOC family protein -
MW396_RS20395 (4153150) 4153150..4154271 + 1122 WP_000010829.1 M42 family metallopeptidase -
MW396_RS20400 (4154268) 4154268..4154546 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
MW396_RS20405 (4154558) 4154558..4155871 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimB 4142043..4151562 9519
flank IS/Tn - - 4147603..4148583 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T242376 WP_001054376.1 NZ_CP095538:4150748-4151005 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T242376 NZ_OW052571:1255891-1256247 [Mycobacterium tuberculosis]
GTGATGCGCCGCGGTGAGATTTGGCAGGTCGATCTCGACCCCGCTCGAGGTAGCGAAGCGAACAACCAGCGCCCCGCCGT
CGTCGTCAGCAACGACCGGGCCAACGCGACCGCCACGCGTCTTGGGCGCGGCGTCATCACCGTCGTGCCGGTGACGAGCA
ACATCGCCAAGGTCTATCCGTTTCAGGTGTTGTTGTCGGCCACCACTACTGGTCTCCAGGTCGACTGCAAGGCGCAGGCC
GAGCAAATCAGATCGATTGCTACCGAGCGGTTGCTCCGGCCAATCGGCCGAGTTTCAGCCGCCGAACTTGCCCAGCTCGA
TGAGGCTTTGAAACTGCATCTCGACTTATGGTCGTAG

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT242376 WP_001309181.1 NZ_CP095538:4151017-4151562 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT242376 NZ_OW052571:1255677-1255907 [Mycobacterium tuberculosis]
GTGAAGTTGAGCGTGAGCCTGTCCGATGACGACGTCGCGATCCTGGACGCATATGTGAAACGAGCGGGATTACCATCCCG
CTCCGCCGGCCTGCAGCATGCGATCCGCGTGCTTCGCTACCCCACGCTCGAAGATGACTATGCCAACGCATGGCAAGAAT
GGTCGGCAGCCGGCGACACGGACGCGTGGGAGCAGACCGTCGGCGACGGAGTCGGTGATGCGCCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References