Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 1310477..1311291 Replicon chromosome
Accession NZ_CP063492
Organism Escherichia coli strain EF5-18-41

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag IQS14_RS06280 Protein ID WP_001054376.1
Coordinates 1311034..1311291 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag IQS14_RS06275 Protein ID WP_001309181.1
Coordinates 1310477..1311022 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IQS14_RS06245 1306168..1307481 - 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -
IQS14_RS06250 1307493..1307771 - 279 WP_000722973.1 PTS sugar transporter subunit IIB -
IQS14_RS06255 1307768..1308889 - 1122 WP_000010829.1 M42 family metallopeptidase -
IQS14_RS06260 1309134..1309250 - 117 Protein_1212 VOC family protein -
IQS14_RS06265 1309288..1309506 - 219 Protein_1213 hypothetical protein -
IQS14_RS06270 1309675..1310421 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
IQS14_RS06275 1310477..1311022 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
IQS14_RS06280 1311034..1311291 - 258 WP_001054376.1 hypothetical protein Toxin
IQS14_RS06285 1311668..1311913 - 246 Protein_1217 GNAT family N-acetyltransferase -
IQS14_RS06290 1312029..1313269 + 1241 Protein_1218 DNA helicase -
IQS14_RS06295 1313420..1314436 + 1017 WP_001322394.1 IS5-like element IS5 family transposase -
IQS14_RS06300 1315051..1316031 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1313456..1314436 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T178471 WP_001054376.1 NZ_CP063492:c1311291-1311034 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T178471 NZ_CP084031:c4642821-4641502 [Aeromonas caviae]
ATGGCCAATCTGGCTGTCTATATGAACGGCTATCGGGTAGGCACATTCACCAAAACTACCAGCGGCGCCCATCATTTTCA
GTACCATGAGTCATGGCTAGCACAACCGGGCAGCCGTCCGATCTCACTCTCCATGCCATTGCGCCATCAGACCTACCGGG
GCGATGAAGCCTATAACTTCTTCGACAACCTGCTGCCAGATAATACGGAGGTGAGAAACAGGGTTGTAGCACGCTATCAA
GCGGCATCAACCCAGCCCTTCGATCTGCTCAGTTGCATTGGCCAGGATAGCGTAGGGGCATTACAGCTGGTTACCGAAGG
GCACGATGTTCCAGATGTCAGGCGAATCGACTACAAGGCACTTTCCGATGACGAGCTCGAGCAGATCCTGACCAGCTACA
AATCAGGAATCCCTTTGGGGATGGTCAGGGAGCAAGAGGAGTTCCGGATCTCTATCGCCGGGGCGCAAGAAAAGACTGCA
CTGCTCTATCTCGATGGCCGTTGGTACTTGCCACTCAATGCAACGCCGACAACCCACATAATCAAACTCCCTATCGGCAA
GATTGAAAGCCACTCCTACTCGATAGACCTCTCCCAGAGCGTAGAAAACGAATATCTCTGCACTCTGATTGCCAAGGAGT
TTGGTCTACCCGTACCTCACTGCTTCATGATGCAGGTTGGCCAGGTCAAAGCACTGGCTGTGGAACGCTTCGACAGACGT
TACGCTGCCGATCGCAGTTGGATCATGCGCCTTCCCCAAGAAGATTTCTGTCAGGTATTGAATGTTCCGTCAGCACGGAA
ATACGAGAACCATGGAGGACCGGGGATCACTGACATCATGAAAACCTTGCTGGGCTCTGCGACACCAGAACAGGATCGCT
ACCTATTCATGAAATCTCAGGTCCTGTTCTGGCTGCTGGCGGCCACCGATGGCCATGCAAAAAACTTCTCGGTCTTTATT
GAGCCGGAAGGGCGTTTTCGCCTGACCCCTTTTTACGACATCCTATCTGTCTATCCAGTATTTGGCGGCCGAGGCCTCAA
CCGAAGGGACGCCAAGCTCGCTATGGGCCTAGCAAGCAGCAAGGGAAAGAAGTACGCCATTGAGCAGATATTCCCGCGTC
ATTTCTTCCAAACGGCGAAAGCTGTGGGATTTGAGCGTTCTGCTATGGAAGAGATCCTGACAGAACTGGCCAACTCCGTT
GATGATGTTATTGAGCGCGTTACACAGCAATTGCCAGCAGGCTTCCCCGATACCATCAGCAGCACCATTCTAGAGGGCCT
AAAAGCCCGCTCAGCCAGGCTGATAAAGGGCTGGGATTAA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT178471 WP_001309181.1 NZ_CP063492:c1311022-1310477 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT178471 NZ_CP084031:c4643075-4642821 [Aeromonas caviae]
ATGAAAGTAACCAGCGCCAAGCAGCTGAGCGCCTGTATCAAGGATGCCAGGCTTTCTCAAAAGCTCTCTCAAGGCAAAGT
GGCCGAGAAAGTAGGGATTAGGCAAGACACAGTCTCCAGCTTCGAGCTCAACCCTGAGTCCACCAAGCTGGAGACCCTGT
TCAAGATCCTCGCGGCACTCGAGTTGTCAGTGGATATCAAACCCCGCAATGAGTCATCCGAGAGTCCGGCATCGGGCTGG
AAGGAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References